Cep55 centrosomal protein 55 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cep55provided by RGD
Official Full Name: centrosomal protein 55provided by RGD
Primary source: RGD:1305340
See related: EnsemblRapid:ENSRNOG00000016377 AllianceGenome:RGD:1305340
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305340
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Predicted to be located in Flemming body; centrosome; and intercellular bridge. Predicted to be active in midbody. Human ortholog(s) of this gene implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Orthologous to human CEP55 (centrosomal protein 55). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 104.0), Testes (RPKM 59.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (245245272..245260835)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (235832823..235848401)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (256745251..256760794)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Cep55 in the rostral ventrolateral medulla elicits impairment of brain stem cardiovascular regulation.
Title: Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication.

Submit: New GeneRIF Correction

General gene information

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Markers

Cep55 (e-PCR), detects polymorphism
- UniSTS:527285

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cranial skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in cranial skeletal system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in midbody abscission	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
NOT involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
NOT involved_in nucleus organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Flemming body	ISO Inferred from Sequence Orthology more info
located_in Flemming body	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: centrosomal protein of 55 kDa

Names: centrosomal protein 55kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025646.1 → NP_001020817.1 centrosomal protein of 55 kDa

See identical proteins and their annotated locations for NP_001020817.1

Status: PROVISIONAL

Source sequence(s)

BC098013

UniProtKB/Swiss-Prot

Q4V7C8

UniProtKB/TrEMBL

A6I175

Related

ENSRNOP00000022133.4, ENSRNOT00000022133.7

Conserved Domains (3) summary

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55

cl08141
Location:229 → 269

Lipoprotein_20; YfhG lipoprotein

cl19219
Location:256 → 332

DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

245245272..245260835

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231318.5 → XP_006231380.1 centrosomal protein of 55 kDa isoform X1

See identical proteins and their annotated locations for XP_006231380.1

UniProtKB/Swiss-Prot

Q4V7C8

UniProtKB/TrEMBL

A6I175

Conserved Domains (3) summary

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55

cl08141
Location:229 → 269

Lipoprotein_20; YfhG lipoprotein

cl19219
Location:256 → 332

DUF342; Protein of unknown function (DUF342)
XM_006231319.4 → XP_006231381.1 centrosomal protein of 55 kDa isoform X1

See identical proteins and their annotated locations for XP_006231381.1

UniProtKB/Swiss-Prot

Q4V7C8

UniProtKB/TrEMBL

A6I175

Conserved Domains (3) summary

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55

cl08141
Location:229 → 269

Lipoprotein_20; YfhG lipoprotein

cl19219
Location:256 → 332

DUF342; Protein of unknown function (DUF342)
XM_017589049.2 → XP_017444538.1 centrosomal protein of 55 kDa isoform X2

UniProtKB/TrEMBL

A6I175

Conserved Domains (2) summary

TIGR02168
Location:152 → 318

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam12180
Location:94 → 127

EABR; TSG101 and ALIX binding domain of CEP55