Opa1 OPA1, mitochondrial dynamin like GTPase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Opa1provided by RGD
Official Full Name: OPA1, mitochondrial dynamin like GTPaseprovided by RGD
Primary source: RGD:708423
See related: EnsemblRapid:ENSRNOG00000001717 AllianceGenome:RGD:708423
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables kinase binding activity. Involved in several processes, including cellular response to L-glutamate; intracellular distribution of mitochondria; and positive regulation of cellular component organization. Located in mitochondrial inner membrane. Used to study transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; ocular hypertension; rhinitis; and steatotic liver disease. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 466.4), Brain (RPKM 319.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (84612943..84690025, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (71108100..71185170, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (74717600..74793902, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differentiation activates mitochondrial OPA1 processing in myoblast cell lines.
Title: Differentiation activates mitochondrial OPA1 processing in myoblast cell lines.
[Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
Title: [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
Mitochondrial OPA1 cleavage is reversibly activated by differentiation of H9c2 cardiomyoblasts.
Title: Mitochondrial OPA1 cleavage is reversibly activated by differentiation of H9c2 cardiomyoblasts.
Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression.
Title: Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression.
Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats.
Title: Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats.
The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling.
Title: The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling.
We identified a mitochondrial inner membrane fusion protein, Opa1, as one of the key mediators of this process and demonstrated that the suppression of Opa1 expression increases the rate of synchronous automaticity in TBX18-iPMs.
Title: Induced cardiac pacemaker cells survive metabolic stress owing to their low metabolic demand.
evidences have been obtained that ROS-dependent apoptosis is associated with an alteration of mitochondrial cAMP/PKA signal that causes degradation/proteolysis of Sirt3 that, in turn, promotes acetylation and proteolytic processing of OPA1
Title: Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells.
Retinal ischemia-reperfusion (I/R) or hypoxia-reoxygenation (H/R) injury induces Opa1 long isoforms loss.
Title: Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration.
Data indicate that the expression of the dynamin-related GTPase OPA1 increased significantly in the pretreated groups, especially in the pre-exercised ischemia group compared with the non-treated groups.
Title: Exercise pretreatment promotes mitochondrial dynamic protein OPA1 expression after cerebral ischemia in rats.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase-dependent fusogenic activity	IEA Inferred from Electronic Annotation more info
enables GTPase-dependent fusogenic activity	ISO Inferred from Sequence Orthology more info
enables GTPase-dependent fusogenic activity	ISS Inferred from Sequence or Structural Similarity more info
enables cardiolipin binding	IEA Inferred from Electronic Annotation more info
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables cardiolipin binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables membrane bending activity	IEA Inferred from Electronic Annotation more info
enables membrane bending activity	ISO Inferred from Sequence Orthology more info
enables membrane bending activity	ISS Inferred from Sequence or Structural Similarity more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidic acid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in GTP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GTP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in calcium import into the mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
involved_in cochlea development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cristae formation	IEA Inferred from Electronic Annotation more info
involved_in cristae formation	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner mitochondrial membrane organization	ISO Inferred from Sequence Orthology more info
involved_in inner mitochondrial membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular distribution of mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in membrane tubulation	IEA Inferred from Electronic Annotation more info
involved_in membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in membrane tubulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial genome maintenance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial genome maintenance	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial genome maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial inner membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial inner membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial inner membrane fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein complex oligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in response to curcumin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info
involved_in visual perception	ISO Inferred from Sequence Orthology more info
involved_in visual perception	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial crista	IEA Inferred from Electronic Annotation more info
located_in mitochondrial crista	ISO Inferred from Sequence Orthology more info
located_in mitochondrial crista	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynamin-like GTPase OPA1, mitochondrial; dynamin-like 120 kDa protein, mitochondrial

Names: RN protein; mitochondrial OPA1; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1-like protein; optic atrophy protein 1 homolog

NP_598269.3

EC 3.6.5.5

XP_006248559.1

EC 3.6.5.5

XP_006248560.1

EC 3.6.5.5

XP_006248561.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433907.1 → NP_001420836.1 dynamin-like GTPase OPA1, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I6A517, A0A8L2PZL8
NM_001433908.1 → NP_001420837.1 dynamin-like GTPase OPA1, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8L2PZL8
NM_001433909.1 → NP_001420838.1 dynamin-like GTPase OPA1, mitochondrial isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8L2PZL8, A0A8L2Q0I8
NM_001433910.1 → NP_001420839.1 dynamin-like GTPase OPA1, mitochondrial isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I5ZZK0, A0A8L2PZL8
NM_001433911.1 → NP_001420840.1 dynamin-like GTPase OPA1, mitochondrial isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8L2PZL8
NM_133585.4 → NP_598269.3 dynamin-like GTPase OPA1, mitochondrial isoform 4 precursor

See identical proteins and their annotated locations for NP_598269.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

O08681, Q2TA68, Q5MPP1, Q5MPP2, Q5QJE9, Q6B435, Q6R611

UniProtKB/TrEMBL

A0A8L2PZL8

Related

ENSRNOP00000084440.1, ENSRNOT00000117359.2

Conserved Domains (1) summary

cd08771
Location:287 → 561

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

84612943..84690025 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248498.3 → XP_006248560.1 dynamin-like 120 kDa protein, mitochondrial isoform X2

Related

ENSRNOP00000079139.1, ENSRNOT00000111984.2

Conserved Domains (1) summary

cd08771
Location:324 → 598

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
XM_006248497.3 → XP_006248559.1 dynamin-like 120 kDa protein, mitochondrial isoform X1

Related

ENSRNOP00000086026.1, ENSRNOT00000104752.2

Conserved Domains (1) summary

cd08771
Location:342 → 616

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
XM_006248499.3 → XP_006248561.1 dynamin-like 120 kDa protein, mitochondrial isoform X3

Related

ENSRNOP00000002343.7, ENSRNOT00000002343.9

Conserved Domains (1) summary

cd08771
Location:305 → 579

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins