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    Sqor sulfide quinone oxidoreductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691966, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sqorprovided by RGD
    Official Full Name
    sulfide quinone oxidoreductaseprovided by RGD
    Primary source
    RGD:1564504
    See related
    EnsemblRapid:ENSRNOG00000000172 AllianceGenome:RGD:1564504
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sqrdl; Cc2-17
    Summary
    Predicted to enable FAD binding activity; glutathione-dependent sulfide quinone oxidoreductase activity; and sulfide:quinone oxidoreductase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human SQOR (sulfide quinone oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 470.4), Lung (RPKM 241.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sqor in Genome Data Viewer
    Location:
    3q35
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (130294783..130341655)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (109841225..109886724)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (114894944..114939375)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 4 Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 6 Neighboring gene uncharacterized LOC120101646 Neighboring gene oogenesin-3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Use of Tissue Metabolite Analysis and Enzyme Kinetics To Discriminate between Alternate Pathways for Hydrogen Sulfide Metabolism. Augustyn KD, et al. Biochemistry, 2017 Feb 21. PMID 28107627, Free PMC Article
    2. The vertebrate homolog of sulfide-quinone reductase is expressed in mitochondria of neuronal tissues. Ackermann M, et al. Neuroscience, 2011 Dec 29. PMID 22067608
    3. The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria. Ackermann M, et al. Cell Tissue Res, 2014 Dec. PMID 25130143
    4. Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite. Jackson MR, et al. Biochemistry, 2012 Aug 28. PMID 22852582
    5. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of Sqor in hydrogen sulfide metabolism in the heart and liver
      Title: Use of Tissue Metabolite Analysis and Enzyme Kinetics To Discriminate between Alternate Pathways for Hydrogen Sulfide Metabolism.
    2. The present report demonstrates the presence and specific localization of SQRDL in various mammalian tissues.
      Title: The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria.
    3. we demonstrated that the SQRDL protein is expressed in neurons, oligodendrocytes, and endothelial cells
      Title: The vertebrate homolog of sulfide-quinone reductase is expressed in mitochondria of neuronal tissues.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione-dependent sulfide quinone oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfide:quinone oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfide:quinone oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfide oxidation, using sulfide:quinone oxidoreductase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfide oxidation, using sulfide:quinone oxidoreductase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfide:quinone oxidoreductase, mitochondrial
    NP_001041378.2
    XP_006234949.1
    XP_038961819.1
    XP_038961820.1
    XP_063140667.1
    XP_063140668.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047913.2 → NP_001041378.2  sulfide:quinone oxidoreductase, mitochondrial

      See identical proteins and their annotated locations for NP_001041378.2

      Status: PROVISIONAL

      Source sequence(s)
      BC158559
      UniProtKB/TrEMBL
      A0A8I6AAA2, A0A9K3Y7D1, B0BMT9, F1M5R5
      Related
      ENSRNOP00000061547.2, ENSRNOT00000068129.5
      Conserved Domains (1) summary
      COG0446
      Location:46 → 425
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      130294783..130341655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234887.5 → XP_006234949.1  sulfide:quinone oxidoreductase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006234949.1

      UniProtKB/TrEMBL
      A0A8I6AAA2, A0A9K3Y7D1, B0BMT9, F1M5R5
      Conserved Domains (1) summary
      COG0446
      Location:46 → 425
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    2. XM_039105892.2 → XP_038961820.1  sulfide:quinone oxidoreductase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I6A347, A0A8I6AAA2
      Conserved Domains (1) summary
      COG0446
      Location:46 → 425
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    3. XM_063284598.1 → XP_063140668.1  sulfide:quinone oxidoreductase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I6A347, A0A8I6AAA2
      Related
      ENSRNOP00000085049.1, ENSRNOT00000094867.2

    4. XM_063284597.1 → XP_063140667.1  sulfide:quinone oxidoreductase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAA2, A0A9K3Y7D1, B0BMT9, F1M5R5

    5. XM_039105891.2 → XP_038961819.1  sulfide:quinone oxidoreductase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAA2, A0A9K3Y7D1, B0BMT9, F1M5R5
      Conserved Domains (1) summary
      COG0446
      Location:46 → 425
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version

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