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    Gigyf1 GRB10 interacting GYF protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304378, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gigyf1provided by RGD
    Official Full Name
    GRB10 interacting GYF protein 1provided by RGD
    Primary source
    RGD:1309933
    See related
    EnsemblRapid:ENSRNOG00000001410 AllianceGenome:RGD:1309933
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Perq1
    Summary
    Predicted to be involved in insulin-like growth factor receptor signaling pathway. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human GIGYF1 (GRB10 interacting GYF protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 111.6), Kidney (RPKM 101.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gigyf1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24800996..24819719, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19166070..19181570, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22234296..22251898, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein Sm D1-like Neighboring gene G protein subunit beta 2 Neighboring gene POP7 homolog, ribonuclease P/MRP subunit Neighboring gene erythropoietin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. Giovannone B, et al. J Biol Chem, 2003 Aug 22. PMID 12771153
    2. Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. Ajiro M, et al. Int J Oncol, 2010 Nov. PMID 20878056
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GRB10-interacting GYF protein 1
    Names
    PERQ amino acid rich, with GYF domain 1
    PERQ amino acid-rich with GYF domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107133.1 → NP_001100603.1  GRB10-interacting GYF protein 1

      See identical proteins and their annotated locations for NP_001100603.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J025, D3ZQJ3
      Related
      ENSRNOP00000001912.4, ENSRNOT00000001912.7
      Conserved Domains (1) summary
      cd00072
      Location:475 → 528
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      24800996..24819719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089418.2 → XP_038945346.1  GRB10-interacting GYF protein 1 isoform X5

      Conserved Domains (2) summary
      PRK12678
      Location:106 → 289
      PRK12678; transcription termination factor Rho; Provisional
      cd00072
      Location:462 → 515
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    2. XM_039089417.2 → XP_038945345.1  GRB10-interacting GYF protein 1 isoform X3

      Conserved Domains (2) summary
      PRK12678
      Location:112 → 265
      PRK12678; transcription termination factor Rho; Provisional
      cd00072
      Location:474 → 527
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    3. XM_006249153.4 → XP_006249215.1  GRB10-interacting GYF protein 1 isoform X2

      Conserved Domains (1) summary
      cd00072
      Location:474 → 527
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    4. XM_063271282.1 → XP_063127352.1  GRB10-interacting GYF protein 1 isoform X4

    5. XM_017598327.3 → XP_017453816.1  GRB10-interacting GYF protein 1 isoform X1

      UniProtKB/TrEMBL
      A6J025, D3ZQJ3
      Conserved Domains (1) summary
      cd00072
      Location:475 → 528
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    Nucleotide Protein Strain
    Heading Accession and Version

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