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    Adam4 a disintegrin and metalloprotease domain 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam4provided by RGD
    Official Full Name
    a disintegrin and metalloprotease domain 4provided by RGD
    Primary source
    RGD:621470
    See related
    AllianceGenome:RGD:621470
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    tMDCV
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Adam4 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (106854533..106856979, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (101123284..101125730, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (105158024..105160470, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member A3 Neighboring gene uncharacterized LOC120103571 Neighboring gene uncharacterized LOC134479222 Neighboring gene cytochrome c oxidase assembly factor COX16 Neighboring gene a disintegrin and metallopeptidase domain 4-like 1 Neighboring gene uncharacterized LOC134479224 Neighboring gene synaptojanin 2 binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, et al. Mol Reprod Dev, 1997 Oct. PMID 9291465
    2. Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. Cho C, et al. Genomics, 1996 Jun 15. PMID 8786143
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125044

    General protein information

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    Preferred Names
    a disintegrin and metalloprotease domain 4
    Names
    a disintegrin and metalloprotease domain (ADAM) 4
    tMDC V

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020305.1 → NP_064701.1  a disintegrin and metalloprotease domain 4 precursor

      See identical proteins and their annotated locations for NP_064701.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107437
      UniProtKB/TrEMBL
      Q3B7V9
      Conserved Domains (5) summary
      smart00050
      Location:427 → 501
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:503 → 644
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213 → 405
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:213 → 394
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:60 → 163
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      106854533..106856979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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