Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hsd3b2provided by RGD
Full Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2provided by RGD
Primary source: RGD:67377
See related: EnsemblRapid:ENSRNOG00000019441 AllianceGenome:RGD:67377
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsd3b1; Hsd3b6; Hsd3b2l1
Summary: Enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity and steroid delta-isomerase activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum; intercellular bridge; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of hyperprolactinemia and hypertension. Human ortholog(s) of this gene implicated in hypospadias. Orthologous to human HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 8657.9) See more
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Genomic context

Location:: 2q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (188784614..188812535, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (186095897..186105354, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (200712895..200722429, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lycopene protects against PCB-induced changes in Leydig cellular StAR protein, cytochrome P450 scc expression and activity of 3beta-HSD.
Title: Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats.
The expression of 3 beta-HSD, a converting enzyme of progesterone, is increased in dorsal root ganglion neurons following peripheral nerve injury.
Title: Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury.
The present studies showed differences in AR and 3beta-HSD distribution within various generations of corpora lutea (CL) and within particular regions of the same young CL.
Title: Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat.

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General gene information

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Markers

RH139877 (e-PCR)
- UniSTS:221961

RH128688 (e-PCR)
- UniSTS:211996

HSD3B (e-PCR)
- UniSTS:254020

Hsd3b1 (e-PCR), detects polymorphism
- UniSTS:257099

RH131337 (e-PCR)
- UniSTS:214620

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables isomerase activity	TAS Traceable Author Statement more info	PubMed
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables steroid delta-isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid delta-isomerase activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase [NAD(P)+] activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in C21-steroid hormone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in C21-steroid hormone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in Leydig cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in androgen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in androgen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4

Names: 3 beta-hydroxysteroid dehydrogenase 6; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV; 3-beta-HSD IV; Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6; hydroxysteroid dehydrogenase-6 delta<5>-3-beta

NP_058961.4

EC 1.1.1.145

EC 5.3.3.1

XP_063137742.1

EC 1.1.1.145

EC 5.3.3.1

XP_063137743.1

EC 1.1.1.145

EC 5.3.3.1

XP_063137744.1

EC 1.1.1.145

EC 5.3.3.1

XP_063137745.1

EC 1.1.1.145

EC 5.3.3.1

XP_063137746.1

EC 1.1.1.145

EC 5.3.3.1

XP_063137747.1

EC 1.1.1.145

EC 5.3.3.1

XP_063137748.1

EC 1.1.1.145

EC 5.3.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017265.4 → NP_058961.4 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4

See identical proteins and their annotated locations for NP_058961.4

Status: PROVISIONAL

Source sequence(s)

BC089937

UniProtKB/Swiss-Prot

Q5FVK0, Q62878

UniProtKB/TrEMBL

A6K3E0, F1LNS3

Related

ENSRNOP00000026306.4, ENSRNOT00000026306.7

Conserved Domains (2) summary

pfam01073
Location:7 → 287

3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family

cl21454
Location:5 → 357

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

188784614..188812535 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281678.1 → XP_063137748.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

UniProtKB/Swiss-Prot

Q5FVK0, Q62878

UniProtKB/TrEMBL

A6K3E0, F1LNS3
XM_063281676.1 → XP_063137746.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

UniProtKB/Swiss-Prot

Q5FVK0, Q62878

UniProtKB/TrEMBL

A6K3E0, F1LNS3
XM_063281677.1 → XP_063137747.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

UniProtKB/Swiss-Prot

Q5FVK0, Q62878

UniProtKB/TrEMBL

A6K3E0, F1LNS3
XM_063281674.1 → XP_063137744.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

UniProtKB/Swiss-Prot

Q5FVK0, Q62878

UniProtKB/TrEMBL

A6K3E0, F1LNS3
XM_063281672.1 → XP_063137742.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

UniProtKB/Swiss-Prot

Q5FVK0, Q62878

UniProtKB/TrEMBL

A6K3E0, F1LNS3
XM_063281673.1 → XP_063137743.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

UniProtKB/Swiss-Prot

Q5FVK0, Q62878

UniProtKB/TrEMBL

A6K3E0, F1LNS3
XM_063281675.1 → XP_063137745.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

UniProtKB/Swiss-Prot

Q5FVK0, Q62878

UniProtKB/TrEMBL

A6K3E0, F1LNS3