Wasf1 WASP family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wasf1provided by RGD
Official Full Name: WASP family member 1provided by RGD
Primary source: RGD:1561954
See related: EnsemblRapid:ENSRNOG00000047476 AllianceGenome:RGD:1561954
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in dendritic transport of mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium and postsynapse. Orthologous to human WASF1 (WASP family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 87.4), Testes (RPKM 32.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (45908458..45956118)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (44325815..44372999)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (48456191..48503768, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the control of actin polymerization and branching via moesin or WAVE1 is a key function of estrogen receptor alpha in neurons, which may be particularly relevant for the regulation of dendritic spines
Title: Rapid signaling of estrogen to WAVE1 and moesin controls neuronal spine formation via the actin cytoskeleton.
Together, these data demonstrate a role for WAVE1 in oligodendrocyte morphogenesis and myelination.
Title: WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.
The WAVE1 G-protein regulatory (GPR) peptide inhibited GTPgammaS binding to purified G-protein.A WAVE1-G-protein complex was also observed following transfection of COS7 cells with Gialpha3 and WAVE1.
Title: Identification and characterization of a G-protein regulatory motif in WAVE1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH144530 (e-PCR)
- UniSTS:233775

1634 (e-PCR)
- UniSTS:49530

Wasf1 (e-PCR), detects polymorphism
- UniSTS:256992

RH134288 (e-PCR)
- UniSTS:217570

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
contributes_to small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendrite extension	IEA Inferred from Electronic Annotation more info
involved_in dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in dendritic transport of mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic transport of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellipodium morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in modification of postsynaptic actin cytoskeleton	IEA Inferred from Electronic Annotation more info
involved_in modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	IEA Inferred from Electronic Annotation more info
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: actin-binding protein WASF1

Names: WAS protein family, member 1; WASP family 1; WASP family protein member 1; protein WAVE-1; wiskott-Aldrich syndrome protein family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025114.2 → NP_001020285.1 actin-binding protein WASF1 isoform 1

See identical proteins and their annotated locations for NP_001020285.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q5BJU7

UniProtKB/TrEMBL

A0A8L2QX68, A6KTC6

Conserved Domains (1) summary

pfam02205
Location:494 → 521

WH2; WH2 motif
NM_001434624.1 → NP_001421553.1 actin-binding protein WASF1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q5BJU7

UniProtKB/TrEMBL

A0A8L2QX68, A6KTC6
NM_001434625.1 → NP_001421554.1 actin-binding protein WASF1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8L2QX68

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

45908458..45956118

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256586.5 → XP_006256648.1 actin-binding protein WASF1 isoform X1

Related

ENSRNOP00000064342.3, ENSRNOT00000073091.4

Conserved Domains (1) summary

pfam02205
Location:494 → 521

WH2; WH2 motif
XM_006256587.5 → XP_006256649.1 actin-binding protein WASF1 isoform X2

Conserved Domains (1) summary

pfam02205
Location:493 → 520

WH2; WH2 motif