Stk40 serine/threonine kinase 40 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stk40provided by RGD
Official Full Name: serine/threonine kinase 40provided by RGD
Primary source: RGD:727884
See related: EnsemblRapid:ENSRNOG00000025679 AllianceGenome:RGD:727884
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lyk4; RGD1307310
Summary: Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to be involved in regulation of MAPK cascade. Predicted to act upstream of or within several processes, including glycogen metabolic process; lung development; and respiratory system process. Predicted to be located in cytosol and nucleoplasm. Orthologous to human STK40 (serine/threonine kinase 40). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 91.8), Muscle (RPKM 84.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (143660438..143702336)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (138380049..138417802)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (144112612..144150653)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Stk40 (e-PCR), detects polymorphism
- UniSTS:472841

Stk40 (e-PCR), detects polymorphism
- UniSTS:472842

UniSTS:235027 (e-PCR)
- UniSTS:235027

RH126883 (e-PCR)
- UniSTS:207676

AA801260 (e-PCR)
- UniSTS:249935

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lung morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in respiratory system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory system process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase 40

Names: Ser/Thr-like protein kinase lyk4; serine/threonine-protein kinase lyk4

NP_898879.2

EC 2.7.11.1

XP_006238943.1

EC 2.7.11.1

XP_038966080.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183056.2 → NP_898879.2 serine/threonine-protein kinase 40

See identical proteins and their annotated locations for NP_898879.2

Status: PROVISIONAL

Source sequence(s)

BC100062

UniProtKB/Swiss-Prot

Q498V1, Q7TNL4

UniProtKB/TrEMBL

A0A0G2JST8

Conserved Domains (2) summary

smart00220
Location:52 → 326

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13974
Location:38 → 330

STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

143660438..143702336

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238881.5 → XP_006238943.1 serine/threonine-protein kinase 40 isoform X1

See identical proteins and their annotated locations for XP_006238943.1

UniProtKB/Swiss-Prot

Q498V1, Q7TNL4

UniProtKB/TrEMBL

A0A0G2JST8

Related

ENSRNOP00000032827.4, ENSRNOT00000035597.6

Conserved Domains (2) summary

smart00220
Location:52 → 326

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13974
Location:38 → 330

STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
XM_039110152.2 → XP_038966080.1 serine/threonine-protein kinase 40 isoform X2

Conserved Domains (1) summary

cl21453
Location:38 → 207

PKc_like; Protein Kinases, catalytic domain