Uqcrc2 ubiquinol cytochrome c reductase core protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uqcrc2provided by RGD
Official Full Name: ubiquinol cytochrome c reductase core protein 2provided by RGD
Primary source: RGD:1359150
See related: EnsemblRapid:ENSRNOG00000036742 AllianceGenome:RGD:1359150
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metal ion binding activity and metalloendopeptidase activity. Involved in response to xenobiotic stimulus. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 3931.5), Muscle (RPKM 2363.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (184599240..184629804)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (175167933..175198499)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (190555177..190585741)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteomic analysis revealed that the expression levels of two mitochondrial proteins, cytochrome bc1 complex2 (UQCRC2, the major component of electron transport chain complex III) and aconitase (an enzyme involved in the tricarboxylic acid cycle), were decreased by homocysteine in neural stem cells
Title: Inhibitory effect of homocysteine on rat neural stem cell growth in vitro is associated with reduced protein levels and enzymatic activities of aconitase and respiratory complex III.
A mechanism by which ferulenol inhibits this enzymeand demonstrates that mitochondrial dysfunction is an important determinant in Ferula plant toxicity.
Title: Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127801 (e-PCR)
- UniSTS:211111

Uqcrc2 (e-PCR), detects polymorphism
- UniSTS:527599

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex III	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex III	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome b-c1 complex subunit 2, mitochondrial

Names: complex III subunit 2; core protein II; ubiquinol-cytochrome C reductase complex core protein 2, mitochondrial precursor (Complex III subunit II); ubiquinol-cytochrome c reductase core protein II; ubiquinol-cytochrome-c reductase complex core protein 2

NP_001006971.1

EC 7.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006970.1 → NP_001006971.1 cytochrome b-c1 complex subunit 2, mitochondrial precursor

See identical proteins and their annotated locations for NP_001006971.1

Status: PROVISIONAL

Source sequence(s)

BC083610

UniProtKB/Swiss-Prot

P32551, Q5XIR3

UniProtKB/TrEMBL

A0A8I6A888, A6I8R0

Related

ENSRNOP00000021514.4, ENSRNOT00000021514.7

Conserved Domains (1) summary

COG0612
Location:30 → 435

PqqL; Predicted Zn-dependent peptidase [General function prediction only]