Tpsg1 tryptase gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpsg1provided by RGD
Official Full Name: tryptase gamma 1provided by RGD
Primary source: RGD:631355
See related: EnsemblRapid:ENSRNOG00000018701 AllianceGenome:RGD:631355
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human TPSG1 (tryptase gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 18.4), Heart (RPKM 3.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14889838..14895605)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (14386352..14390258)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14724531..14731259)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tryptase gamma

NP_783183.1

EC 3.4.21.59

XP_063124997.1

EC 3.4.21.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175593.2 → NP_783183.1 tryptase gamma precursor

See identical proteins and their annotated locations for NP_783183.1

Status: PROVISIONAL

Source sequence(s)

AY196208

UniProtKB/TrEMBL

A0A8I6AAZ3, F7ELK9, Q80XZ3

Related

ENSRNOP00000025236.3, ENSRNOT00000025236.5

Conserved Domains (2) summary

smart00020
Location:29 → 257

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:30 → 260

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...