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    Stat3 signal transducer and activator of transcription 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25125, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stat3provided by RGD
    Official Full Name
    signal transducer and activator of transcription 3provided by RGD
    Primary source
    RGD:3772
    See related
    EnsemblRapid:ENSRNOG00000019742 AllianceGenome:RGD:3772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables CCR5 chemokine receptor binding activity; nuclear glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of hydrogen peroxide biosynthetic process; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of nucleobase-containing compound metabolic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; mitochondrial inner membrane; and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Biomarker of atherosclerosis; colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 347.1), Lung (RPKM 285.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stat3 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86311528..86363513, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85811206..85863057, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88790401..88842263, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 5A Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134480717 Neighboring gene caveolae associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93551

    Gene Ontology Provided by RGD

    Items 1 - 25 of 52
    Function Evidence Code Pubs
    enables CCR5 chemokine receptor binding PubMed 
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding PubMed 
    enables DNA-binding transcription factor binding  
    enables RNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA sequestering activity  
    enables RNA sequestering activity  
    enables chromatin DNA binding  
    enables chromatin DNA binding  
    enables chromatin DNA binding  
    enables identical protein binding  
    enables lncRNA binding  
    enables lncRNA binding  
    enables nuclear glucocorticoid receptor binding PubMed 
    enables nuclear receptor activity  
    enables nuclear receptor activity  
    enables primary miRNA binding  
    enables primary miRNA binding  
    enables protein binding PubMed 
    enables protein dimerization activity  
    enables protein dimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables signaling adaptor activity  
    enables signaling adaptor activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 52
    Items 1 - 25 of 181
    Process Evidence Code Pubs
    involved_in T-helper 17 cell lineage commitment  
    involved_in T-helper 17 cell lineage commitment  
    involved_in T-helper 17 cell lineage commitment  
    involved_in T-helper 17 type immune response  
    involved_in acute-phase response PubMed 
    involved_in astrocyte differentiation  
    involved_in astrocyte differentiation  
    involved_in astrocyte differentiation  
    involved_in cell differentiation  
    involved_in cell population proliferation  
    acts_upstream_of_or_within cell population proliferation  
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cell surface receptor signaling pathway via JAK-STAT PubMed 
    involved_in cell surface receptor signaling pathway via STAT  
    acts_upstream_of_or_within cellular response to cytokine stimulus PubMed 
    involved_in cellular response to hormone stimulus  
    involved_in cellular response to interleukin-17  
    involved_in cellular response to interleukin-17  
    involved_in cellular response to leptin stimulus  
    involved_in cellular response to leptin stimulus  
    acts_upstream_of_or_within cellular response to organic cyclic compound PubMed 
    involved_in defense response  
    involved_in eating behavior  
    acts_upstream_of_or_within eating behavior  
    involved_in eating behavior  
    involved_in energy homeostasis  
    involved_in energy homeostasis  
    involved_in energy homeostasis  
    involved_in eye photoreceptor cell differentiation  
    involved_in gene expression  
    involved_in glucose homeostasis  
    acts_upstream_of_or_within glucose homeostasis  
    involved_in glucose homeostasis  
    involved_in glucose homeostasis  
    involved_in growth hormone receptor signaling pathway  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in interleukin-10-mediated signaling pathway  
    involved_in interleukin-10-mediated signaling pathway  
    involved_in interleukin-11-mediated signaling pathway  
    involved_in interleukin-11-mediated signaling pathway  
    involved_in interleukin-15-mediated signaling pathway  
    involved_in interleukin-15-mediated signaling pathway  
    involved_in interleukin-2-mediated signaling pathway  
    involved_in interleukin-2-mediated signaling pathway  
    involved_in interleukin-23-mediated signaling pathway  
    involved_in interleukin-23-mediated signaling pathway  
    involved_in interleukin-6-mediated signaling pathway  
    involved_in interleukin-6-mediated signaling pathway  
    involved_in interleukin-6-mediated signaling pathway  
    involved_in interleukin-9-mediated signaling pathway  
    involved_in interleukin-9-mediated signaling pathway  
    involved_in intracellular receptor signaling pathway  
    involved_in intracellular receptor signaling pathway  
    involved_in leptin-mediated signaling pathway  
    involved_in leptin-mediated signaling pathway  
    involved_in leptin-mediated signaling pathway  
    involved_in leptin-mediated signaling pathway  
    involved_in mRNA transcription by RNA polymerase II  
    acts_upstream_of_or_within mRNA transcription by RNA polymerase II  
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of glycolytic process  
    acts_upstream_of_or_within negative regulation of glycolytic process  
    involved_in negative regulation of hydrogen peroxide biosynthetic process PubMed 
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of inflammatory response to wounding  
    involved_in negative regulation of inflammatory response to wounding  
    involved_in negative regulation of neuron migration  
    acts_upstream_of_or_within negative regulation of neuron migration  
    involved_in negative regulation of primary miRNA processing  
    involved_in negative regulation of primary miRNA processing  
    involved_in negative regulation of stem cell differentiation  
    acts_upstream_of_or_within negative regulation of stem cell differentiation  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphorylation  
    involved_in phosphorylation  
    involved_in positive regulation of ATP biosynthetic process PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation PubMed 
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-10 production  
    involved_in positive regulation of interleukin-10 production  
    acts_upstream_of positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of metalloendopeptidase activity  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of vascular endothelial cell proliferation  
    involved_in positive regulation of vascular endothelial cell proliferation  
    involved_in positive regulation of vascular endothelial growth factor production  
    acts_upstream_of positive regulation of vascular endothelial growth factor production  
    involved_in postsynapse to nucleus signaling pathway PubMed 
    involved_in postsynapse to nucleus signaling pathway PubMed 
    involved_in protein import into nucleus  
    involved_in protein import into nucleus  
    involved_in protein import into nucleus  
    involved_in radial glial cell differentiation  
    involved_in radial glial cell differentiation  
    involved_in radial glial cell differentiation  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of cell population proliferation  
    involved_in regulation of cellular response to hypoxia PubMed 
    involved_in regulation of feeding behavior  
    involved_in regulation of feeding behavior  
    involved_in regulation of feeding behavior  
    involved_in regulation of mitochondrial membrane permeability PubMed 
    involved_in regulation of multicellular organism growth  
    acts_upstream_of_or_within regulation of multicellular organism growth  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to cytokine PubMed 
    involved_in response to estradiol  
    involved_in response to estradiol PubMed 
    involved_in response to estradiol  
    involved_in response to ethanol PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to ischemia PubMed 
    involved_in response to leptin  
    involved_in response to leptin  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to peptide hormone  
    involved_in response to peptide hormone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in retinal rod cell differentiation  
    acts_upstream_of_or_within retinal rod cell differentiation  
    involved_in sexual reproduction  
    acts_upstream_of_or_within sexual reproduction  
    involved_in sexual reproduction  
    involved_in somatic stem cell population maintenance  
    acts_upstream_of_or_within somatic stem cell population maintenance  
    involved_in temperature homeostasis  
    acts_upstream_of_or_within temperature homeostasis  
    involved_in temperature homeostasis  
    acts_upstream_of transcription by RNA polymerase II  
    acts_upstream_of_or_within transcription by RNA polymerase II  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    Items 1 - 25 of 181
    Items 1 - 20 of 32
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in chromatin  
    located_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in mitochondrial inner membrane PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density PubMed 
    part_of protein-containing complex  
    part_of transcription regulator complex  
    Items 1 - 20 of 32

    General protein information

    Preferred Names
    signal transducer and activator of transcription 3
    Names
    signal transducer and activator of transcription 3 (acute-phase response factor)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430046.1NP_001416975.1  signal transducer and activator of transcription 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6GJJ3
    2. NM_001430047.1NP_001416976.1  signal transducer and activator of transcription 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6GJJ3
    3. NM_001430048.1NP_001416977.1  signal transducer and activator of transcription 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6GJJ3
    4. NM_012747.3NP_036879.1  signal transducer and activator of transcription 3 isoform 1

      See identical proteins and their annotated locations for NP_036879.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P52631
      UniProtKB/TrEMBL
      A0A8I6GJJ3, A6HJ64
      Related
      ENSRNOP00000026760.3, ENSRNOT00000026760.6
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86311528..86363513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247257.5XP_006247319.1  signal transducer and activator of transcription 3 isoform X1

      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    2. XM_006247259.5XP_006247321.1  signal transducer and activator of transcription 3 isoform X3

      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    3. XM_006247258.5XP_006247320.1  signal transducer and activator of transcription 3 isoform X2

      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
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