Adcy1 adenylate cyclase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcy1provided by RGD
Official Full Name: adenylate cyclase 1provided by RGD
Primary source: RGD:1309318
See related: EnsemblRapid:ENSRNOG00000059479 AllianceGenome:RGD:1309318
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ac1
Summary: Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in cAMP biosynthetic process; circadian rhythm; and response to xenobiotic stimulus. Predicted to be located in cytoplasm and postsynaptic density. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 605.5), Kidney (RPKM 65.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (86125119..86234459)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (81911240..82020594)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (87311970..87429880)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAP1 binds and activates adenylyl cyclase in mammalian cells.
Title: CAP1 binds and activates adenylyl cyclase in mammalian cells.
Despite previous hints pointing to a major contribution of ACs, the presented data show that there is no apparent causality between AC activity and the occurrence of the epileptic phenotype.
Title: Adenylyl cyclases: expression in the developing rat thalamus and their role in absence epilepsy.
Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.
Title: Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.
expression of Galphas and Galphai protein subunits and adenylate cyclase in rat ovary, breast and pituitary are regulated by Luteinizing hormone-releasing hormone antagonist Cetrorelix
Title: Luteinizing hormone-releasing hormone antagonist Cetrorelix regulates the expression of Galphas and Galphai protein subunits and adenylate cyclase activity in rat ovary, breast and pituitary.
phosphorylated caveolin and adenylyl cyclase have roles in scaffolding myofibroblasts in focal adhesions
Title: Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin.
the circadian clock gates melatonin synthesis in part by regulating the expression of the type 1 adenylyl cyclase (AC1) and the synthesis of cAMP in photoreceptor cells.
Title: Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina.

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General gene information

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Markers

RH138569 (e-PCR)
- UniSTS:220656

RH143186 (e-PCR)
- UniSTS:232433

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables calcium- and calmodulin-responsive adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term memory	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon hillock	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylate cyclase type 1

Names: adenylate cyclase 1 (brain)

NP_001100709.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107239.1 → NP_001100709.1 adenylate cyclase type 1

See identical proteins and their annotated locations for NP_001100709.1

Status: PROVISIONAL

Source sequence(s)

CH474055

UniProtKB/TrEMBL

A6KJ71, D4A3N4

Related

ENSRNOP00000107758.1, ENSRNOT00000162156.1

Conserved Domains (3) summary

smart00044
Location:105 → 300

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:706 → 903

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:6 → 139

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region