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    Tgds TDP-glucose 4,6-dehydratase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306164, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tgdsprovided by RGD
    Official Full Name
    TDP-glucose 4,6-dehydrataseprovided by RGD
    Primary source
    RGD:1306544
    See related
    EnsemblRapid:ENSRNOG00000009661 AllianceGenome:RGD:1306544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dTDP-glucose 4,6-dehydratase activity. Predicted to be involved in nucleotide-sugar metabolic process. Human ortholog(s) of this gene implicated in Catel Manzke syndrome. Orthologous to human TGDS (TDP-glucose 4,6-dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 96.5), Thymus (RPKM 95.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tgds in Genome Data Viewer
    Location:
    15q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (101581765..101602779, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (95175064..95195555, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (103319268..103340239, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482233 Neighboring gene uncharacterized LOC102548945 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 5 Neighboring gene G protein-coupled receptor 180 Neighboring gene uncharacterized LOC134482020

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dTDP-glucose 4,6-dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleotide-sugar metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dTDP-D-glucose 4,6-dehydratase
    NP_001381658.1
    XP_063130417.1
    XP_063130418.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394729.1 → NP_001381658.1  dTDP-D-glucose 4,6-dehydratase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2JZS4
      Related
      ENSRNOP00000071162.3, ENSRNOT00000088909.3
      Conserved Domains (1) summary
      cd05246
      Location:18 → 336
      dTDP_GD_SDR_e; dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      101581765..101602779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274348.1 → XP_063130418.1  dTDP-D-glucose 4,6-dehydratase isoform X2

    2. XM_063274347.1 → XP_063130417.1  dTDP-D-glucose 4,6-dehydratase isoform X1

    RNA

    1. XR_010057832.1 RNA Sequence

    2. XR_010057831.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107286.1: Suppressed sequence

      Description
      NM_001107286.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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