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    Hjv hemojuvelin BMP co-receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310681, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hjvprovided by RGD
    Official Full Name
    hemojuvelin BMP co-receptorprovided by RGD
    Primary source
    RGD:1310195
    See related
    EnsemblRapid:ENSRNOG00000021200 AllianceGenome:RGD:1310195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hfe2; Rgmc
    Summary
    Predicted to enable BMP binding activity; coreceptor activity; and transferrin receptor binding activity. Predicted to contribute to BMP receptor activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; protein autoprocessing; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within multicellular organismal-level iron ion homeostasis; negative regulation of BMP signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 2A. Orthologous to human HJV (hemojuvelin BMP co-receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 2533.9), Heart (RPKM 466.0) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Hjv in Genome Data Viewer
    Location:
    2q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186754801..186758708)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184065944..184069851)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198655437..198659318)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485659 Neighboring gene transfer RNA glycine (anticodon UCC) 1 Neighboring gene transfer RNA glutamic acid (anticodon CUC) 2 Neighboring gene uncharacterized LOC103691645 Neighboring gene thioredoxin interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC105910

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BMP binding  
    enables BMP binding  
    contributes_to BMP receptor activity  
    enables coreceptor activity  
    enables coreceptor activity  
    enables coreceptor activity  
    enables signaling receptor binding  
    enables transferrin receptor binding  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    involved_in BMP signaling pathway  
    acts_upstream_of_or_within BMP signaling pathway  
    involved_in BMP signaling pathway  
    involved_in activin receptor signaling pathway  
    involved_in biological_process  
    involved_in cellular response to BMP stimulus  
    involved_in intracellular iron ion homeostasis  
    involved_in intracellular iron ion homeostasis  
    involved_in multicellular organismal-level iron ion homeostasis  
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis  
    involved_in negative regulation of BMP signaling pathway  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein autoprocessing  
    involved_in transcription by RNA polymerase II  
    acts_upstream_of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    part_of BMP receptor complex  
    part_of HFE-transferrin receptor complex  
    located_in basolateral plasma membrane PubMed 
    located_in cell surface  
    located_in cell surface  
    located_in extracellular space  
    located_in extracellular space  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of plasma membrane protein complex  
    located_in side of membrane  

    General protein information

    Preferred Names
    hemojuvelin
    Names
    RGM domain family member C
    hemochromatosis type 2 (juvenile) (human homolog)
    hemochromatosis type 2 protein homolog
    hemojuvelin BMP coreceptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012080.2NP_001012080.1  hemojuvelin precursor

      See identical proteins and their annotated locations for NP_001012080.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q8N7M5
      UniProtKB/TrEMBL
      F7FBV5, Q5FWU4
      Related
      ENSRNOP00000028781.4, ENSRNOT00000028781.8
      Conserved Domains (2) summary
      pfam06534
      Location:226384
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:37221
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186754801..186758708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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