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    Mcoln3 mucolipin TRP cation channel 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcoln3provided by RGD
    Official Full Name
    mucolipin TRP cation channel 3provided by RGD
    Primary source
    RGD:1308420
    See related
    EnsemblRapid:ENSRNOG00000015024 AllianceGenome:RGD:1308420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NAADP-sensitive calcium-release channel activity. Predicted to be involved in calcium-mediated signaling and monoatomic ion transmembrane transport. Predicted to act upstream of or within inner ear auditory receptor cell differentiation; locomotory behavior; and sensory perception of sound. Predicted to be located in cytoplasm. Predicted to be active in lysosomal membrane and plasma membrane. Orthologous to human MCOLN3 (mucolipin TRP cation channel 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 98.2), Spleen (RPKM 62.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcoln3 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (237596544..237705770)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235008716..235042885)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (251930532..252007722)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485992 Neighboring gene synapse defective Rho GTPase homolog 2 Neighboring gene dynein axonemal intermediate chain 3 Neighboring gene mucolipin TRP cation channel 2 Neighboring gene lysophosphatidic acid receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Di Palma F, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12403827, Free PMC Article
    2. Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Calderon A, et al. Hear Res, 2006 Nov. PMID 16962269
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAADP-sensitive calcium-release channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inner ear auditory receptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mucolipin-3
    Names
    mucolipin 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012059.2 → NP_001012059.1  mucolipin-3

      See identical proteins and their annotated locations for NP_001012059.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZXW7, E9PT54, Q6AY44
      Related
      ENSRNOP00000107864.1, ENSRNOT00000138110.1
      Conserved Domains (2) summary
      pfam08016
      Location:343 → 508
      PKD_channel; Polycystin cation channel
      cd21072
      Location:109 → 277
      ELD_TRPML3; extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      237596544..237705770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281683.1 → XP_063137753.1  mucolipin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXW7, E9PT54, Q6AY44

    2. XM_063281684.1 → XP_063137754.1  mucolipin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXW7, E9PT54, Q6AY44

    3. XM_039102139.2 → XP_038958067.1  mucolipin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXW7, E9PT54, Q6AY44
      Related
      ENSRNOP00000110424.1, ENSRNOT00000151289.1
      Conserved Domains (2) summary
      pfam08016
      Location:343 → 508
      PKD_channel; Polycystin cation channel
      cd21072
      Location:109 → 277
      ELD_TRPML3; extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3)
    Nucleotide Protein Strain
    Heading Accession and Version

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