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    Trim10 tripartite motif-containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294210, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trim10provided by RGD
    Official Full Name
    tripartite motif-containing 10provided by RGD
    Primary source
    RGD:1359438
    See related
    EnsemblRapid:ENSRNOG00000000782 AllianceGenome:RGD:1359438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf9; Rfb30
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and negative regulation of viral entry into host cell. Predicted to act upstream of or within erythrocyte differentiation. Predicted to be active in cytoplasm. Orthologous to human TRIM10 (tripartite motif containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 105.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trim10 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (1694771..1703724, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (1689554..1698948, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2182945..2191640, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein 39 pseudogene 1 Neighboring gene Pbp pseudogene Neighboring gene tripartite motif containing 15 Neighboring gene tripartite motif-containing 15, pseudogene 1 Neighboring gene tripartite motif-containing 26 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Silencing of TRIM10 alleviates apoptosis in cellular model of Parkinson's disease. Huang Q, et al. Biochem Biophys Res Commun, 2019 Oct 20. PMID 31472958
    2. Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway. Yang H, et al. J Cell Mol Med, 2020 Jun. PMID 32343488, Free PMC Article
    3. HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. Harada H, et al. Mol Cell Biol, 1999 May. PMID 10207104, Free PMC Article
    4. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. Uchil PD, et al. PLoS Pathog, 2008 Feb 8. PMID 18248090, Free PMC Article
    5. The tripartite motif family identifies cell compartments. Reymond A, et al. EMBO J, 2001 May 1. PMID 11331580, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 10
    Names
    tripartite motif protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009176.2 → NP_001009176.1  tripartite motif-containing protein 10

      See identical proteins and their annotated locations for NP_001009176.1

      Status: VALIDATED

      Source sequence(s)
      BC129078
      UniProtKB/TrEMBL
      A1L1I7, Q6MFY9
      Related
      ENSRNOP00000001016.5, ENSRNOT00000001016.9
      Conserved Domains (4) summary
      cd00021
      Location:97 → 135
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam15227
      Location:16 → 60
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd15827
      Location:309 → 480
      SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
      cl23765
      Location:143 → 217
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      1694771..1703724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278992.1 → XP_063135062.1  tripartite motif-containing protein 10 isoform X1

    2. XM_063278993.1 → XP_063135063.1  tripartite motif-containing protein 10 isoform X2

    3. XM_039098472.2 → XP_038954400.1  tripartite motif-containing protein 10 isoform X3

      Conserved Domains (4) summary
      smart00502
      Location:150 → 224
      BBC; B-Box C-terminal domain
      cd15827
      Location:316 → 487
      SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
      cd16593
      Location:13 → 61
      RING-HC_TRIM10_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins
      cl00034
      Location:99 → 135
      Bbox_SF; B-box-type zinc finger superfamily

    4. XM_039098474.2 → XP_038954402.1  tripartite motif-containing protein 10 isoform X6

      Conserved Domains (4) summary
      smart00502
      Location:150 → 224
      BBC; B-Box C-terminal domain
      cd00162
      Location:16 → 60
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:99 → 135
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:13 → 61
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    5. XM_039098473.2 → XP_038954401.1  tripartite motif-containing protein 10 isoform X5

      Conserved Domains (4) summary
      smart00502
      Location:150 → 224
      BBC; B-Box C-terminal domain
      cd00162
      Location:16 → 60
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:99 → 135
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:13 → 61
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    6. XM_063278994.1 → XP_063135064.1  tripartite motif-containing protein 10 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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