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    Tpx2 TPX2, microtubule nucleation factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tpx2provided by RGD
    Official Full Name
    TPX2, microtubule nucleation factorprovided by RGD
    Primary source
    RGD:1311894
    See related
    EnsemblRapid:ENSRNOG00000008165 AllianceGenome:RGD:1311894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable importin-alpha family protein binding activity; molecular adaptor activity; and protein kinase binding activity. Predicted to be involved in activation of protein kinase activity; microtubule cytoskeleton organization; and regulation of microtubule cytoskeleton organization. Predicted to be located in several cellular components, including axon hillock; intercellular bridge; and spindle. Predicted to be active in spindle. Orthologous to human TPX2 (TPX2 microtubule nucleation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 212.7), Spleen (RPKM 144.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpx2 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161778709..161820941)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141318428..141360684)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148327965..148370187)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486188 Neighboring gene cytochrome c oxidase subunit 4i2 Neighboring gene Bcl2-like 1 Neighboring gene ribosomal protein S2, pseudogene 43 Neighboring gene small nucleolar RNA U109 Neighboring gene uncharacterized LOC102553350 Neighboring gene myosin light chain kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. Zhao B, et al. Protein Sci, 2008 Oct. PMID 18662907, Free PMC Article
    2. A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. Bibby RA, et al. J Biol Chem, 2009 Nov 27. PMID 19801554, Free PMC Article
    3. Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. Bird AW, et al. J Cell Biol, 2008 Jul 28. PMID 18663142, Free PMC Article
    4. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Bayliss R, et al. Mol Cell, 2003 Oct. PMID 14580337
    5. Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module. Roostalu J, et al. Nat Cell Biol, 2015 Nov. PMID 26414402, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon hillock ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    targeting protein for Xklp2
    Names
    TPX2, microtubule-associated protein homolog
    TPX2, microtubule-associated, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107790.3 → NP_001101260.1  targeting protein for Xklp2 isoform a

      See identical proteins and their annotated locations for NP_001101260.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ARV3, A6KHR8, D3ZA78
      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:658 → 738
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    2. NM_001434079.1 → NP_001421008.1  targeting protein for Xklp2 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ARV3, A6KHR8, D3ZA78

    3. NM_001434080.1 → NP_001421009.1  targeting protein for Xklp2 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ARV3, A6KHR8, D3ZA78

    4. NM_001434081.1 → NP_001421010.1  targeting protein for Xklp2 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ARV3, A6KHR8, D3ZA78

    5. NM_001434082.1 → NP_001421011.1  targeting protein for Xklp2 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JT92, A0A8I6ARV3

    6. NM_001434083.1 → NP_001421012.1  targeting protein for Xklp2 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JT92, A0A8I6ARV3

    7. NM_001434084.1 → NP_001421013.1  targeting protein for Xklp2 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JT92, A0A8I6ARV3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      161778709..161820941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235273.5 → XP_006235335.1  targeting protein for Xklp2 isoform X1

      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:658 → 738
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    2. XM_039105064.2 → XP_038960992.1  targeting protein for Xklp2 isoform X2

      Related
      ENSRNOP00000097456.2, ENSRNOT00000104440.2
      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:651 → 731
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    3. XM_006235270.5 → XP_006235332.1  targeting protein for Xklp2 isoform X1

      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:658 → 738
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    4. XM_006235274.5 → XP_006235336.1  targeting protein for Xklp2 isoform X2

      Related
      ENSRNOP00000068619.2, ENSRNOT00000088481.3
      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:651 → 731
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    5. XM_006235272.5 → XP_006235334.1  targeting protein for Xklp2 isoform X1

      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:658 → 738
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    6. XM_063283825.1 → XP_063139895.1  targeting protein for Xklp2 isoform X2

    7. XM_039105059.2 → XP_038960987.1  targeting protein for Xklp2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARV3, A6KHR8, D3ZA78
      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:658 → 738
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    8. XM_063283824.1 → XP_063139894.1  targeting protein for Xklp2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JT92, A0A8I6ARV3

    9. XM_039105061.2 → XP_038960989.1  targeting protein for Xklp2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARV3, A6KHR8, D3ZA78
      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:658 → 738
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    10. XM_039105062.2 → XP_038960990.1  targeting protein for Xklp2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARV3, A6KHR8, D3ZA78
      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:658 → 738
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    11. XM_039105060.2 → XP_038960988.1  targeting protein for Xklp2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARV3, A6KHR8, D3ZA78
      Related
      ENSRNOP00000010851.4, ENSRNOT00000010851.7
      Conserved Domains (3) summary
      pfam09041
      Location:1 → 68
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:658 → 738
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:365 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein
    Nucleotide Protein Strain
    Heading Accession and Version

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