Lcn12 lipocalin 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lcn12provided by RGD
Official Full Name: lipocalin 12provided by RGD
Primary source: RGD:1589474
See related: EnsemblRapid:ENSRNOG00000028701 AllianceGenome:RGD:1589474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables retinoic acid binding activity. Predicted to be involved in complement activation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human LCN12 (lipocalin 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 181.6), Adrenal (RPKM 23.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28710557..28713537, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8312412..8315392, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2716547..2719135, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Solution structure of the protein lipocalin 12 from rat epididymis.
Title: Solution structure of the protein lipocalin 12 from rat epididymis.
rLcn12 could be involved in retinoic acid transport in the epididymis
Title: Conformational and biochemical characterization of a rat epididymis-specific lipocalin 12 expressed in Escherichia coli.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables retinoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in complement activation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: epididymal-specific lipocalin-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128138.1 → NP_001121610.1 epididymal-specific lipocalin-12 isoform 2

See identical proteins and their annotated locations for NP_001121610.1

Status: VALIDATED

Source sequence(s)

CH474001

UniProtKB/TrEMBL

A0A0G2JYI8, A6JT73

Conserved Domains (1) summary

pfam00061
Location:4 → 149

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_001395074.1 → NP_001382003.1 epididymal-specific lipocalin-12 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

B3EY83, D3ZI71

UniProtKB/TrEMBL

H9KVE9

Related

ENSRNOP00000101822.1, ENSRNOT00000143624.1

Conserved Domains (1) summary

cd19458
Location:29 → 193

lipocalin_12; Lipocalin 12