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    Kcng1 potassium voltage-gated channel modifier subfamily G member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcng1provided by RGD
    Official Full Name
    potassium voltage-gated channel modifier subfamily G member 1provided by RGD
    Primary source
    RGD:631416
    See related
    EnsemblRapid:ENSRNOG00000054314 AllianceGenome:RGD:631416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kh2; Kv6.1
    Summary
    Enables potassium channel regulator activity. Involved in potassium ion transport and regulation of potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. Orthologous to human KCNG1 (potassium voltage-gated channel modifier subfamily G member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 9.9), Uterus (RPKM 4.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcng1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (177379593..177412986, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (156960717..156992877, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (165020230..165040966, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene activity-dependent neuroprotector homeobox Neighboring gene dolichyl-phosphate mannosyltransferase subunit 1, catalytic Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene uncharacterized LOC134486480 Neighboring gene uncharacterized LOC120101792 Neighboring gene keratin-associated protein 4-3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits. Kramer JW, et al. Am J Physiol, 1998 Jun. PMID 9696692
    2. Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. Drewe JA, et al. J Neurosci, 1992 Feb. PMID 1740690, Free PMC Article
    3. Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. Post MA, et al. FEBS Lett, 1996 Dec 9. PMID 8980147
    4. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. Mederos Y Schnitzler M, et al. J Biol Chem, 2009 Feb 13. PMID 19074135
    5. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, et al. J Biol Chem, 1997 Sep 26. PMID 9305895

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated potassium channel regulatory subunit KCNG1; potassium voltage-gated channel subfamily G member 1
    Names
    potassium channel, voltage-gated modifier subfamily G, member 1
    potassium voltage-gated channel, subfamily G, member 1
    voltage-gated potassium channel subunit Kv6.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106545.2 → NP_001100015.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 1

      See identical proteins and their annotated locations for NP_001100015.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D4AD53
      UniProtKB/TrEMBL
      A0A8I6ARM4
      Related
      ENSRNOP00000069311.1, ENSRNOT00000081648.3
      Conserved Domains (4) summary
      smart00225
      Location:65 → 169
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:256 → 471
      Ion_trans; Ion transport protein
      pfam02214
      Location:65 → 164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383 → 465
      Ion_trans_2; Ion channel

    2. NM_001430296.1 → NP_001417225.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D4AD53
      UniProtKB/TrEMBL
      A0A8I6ARM4

    3. NM_001430297.1 → NP_001417226.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_001430298.1 → NP_001417227.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001430299.1 → NP_001417228.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      177379593..177412986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104646.2 → XP_038960574.1  potassium voltage-gated channel subfamily G member 1 isoform X3

      Conserved Domains (1) summary
      cd18421
      Location:60 → 173
      BTB_POZ_KCNG1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2

    2. XM_063283412.1 → XP_063139482.1  potassium voltage-gated channel subfamily G member 1 isoform X2

    3. XM_017591616.3 → XP_017447105.1  potassium voltage-gated channel subfamily G member 1 isoform X1

      Conserved Domains (4) summary
      smart00225
      Location:65 → 169
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:256 → 471
      Ion_trans; Ion transport protein
      pfam02214
      Location:65 → 164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383 → 465
      Ion_trans_2; Ion channel

    4. XM_039104645.2 → XP_038960573.1  potassium voltage-gated channel subfamily G member 1 isoform X2

      Conserved Domains (1) summary
      cd18421
      Location:60 → 173
      BTB_POZ_KCNG1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2

    5. XM_008762484.4 → XP_008760706.1  potassium voltage-gated channel subfamily G member 1 isoform X1

      Conserved Domains (4) summary
      smart00225
      Location:65 → 169
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:256 → 471
      Ion_trans; Ion transport protein
      pfam02214
      Location:65 → 164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383 → 465
      Ion_trans_2; Ion channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4AD53.1 GenPept UniProtKB/Swiss-Prot:D4AD53

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