Klhdc10 kelch domain containing 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhdc10provided by RGD
Official Full Name: kelch domain containing 10provided by RGD
Primary source: RGD:1309792
See related: EnsemblRapid:ENSRNOG00000010267 AllianceGenome:RGD:1309792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309792
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of stress-activated MAPK cascade; rescue of stalled ribosome; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHDC10 (kelch domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 273.3), Brain (RPKM 233.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (59988710..60046518)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (59021300..59079118)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (57715982..57773800)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BE102215 (e-PCR)
- UniSTS:244098

RH133231 (e-PCR)
- UniSTS:216514

BM389047 (e-PCR)
- UniSTS:261628

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul2-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kelch domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017456.1 → NP_001017456.1 kelch domain-containing protein 10

See identical proteins and their annotated locations for NP_001017456.1

Status: PROVISIONAL

Source sequence(s)

BC085351

UniProtKB/Swiss-Prot

Q5U3Y0

UniProtKB/TrEMBL

A0A8I5ZRC5, A6IEG0

Related

ENSRNOP00000038586.4, ENSRNOT00000034429.6

Conserved Domains (4) summary

PLN02153
Location:107 → 270

PLN02153; epithiospecifier protein

PRK14131
Location:56 → 139

PRK14131; N-acetylneuraminate epimerase

sd00038
Location:176 → 224

Kelch; KELCH repeat [structural motif]

pfam01344
Location:283 → 329

Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

59988710..60046518

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236201.5 → XP_006236263.1 kelch domain-containing protein 10 isoform X1

See identical proteins and their annotated locations for XP_006236263.1

UniProtKB/TrEMBL

A0A0G2KB15, A0A8I5ZRC5

Related

ENSRNOP00000106559.1, ENSRNOT00000096895.2

Conserved Domains (4) summary

PLN02153
Location:136 → 299

PLN02153; epithiospecifier protein

PRK14131
Location:85 → 168

PRK14131; N-acetylneuraminate epimerase

sd00038
Location:205 → 253

Kelch; KELCH repeat [structural motif]

pfam01344
Location:312 → 358

Kelch_1; Kelch motif