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    Pla2g2e phospholipase A2, group IIE [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pla2g2eprovided by RGD
    Official Full Name
    phospholipase A2, group IIEprovided by RGD
    Primary source
    RGD:1309611
    See related
    EnsemblRapid:ENSRNOG00000017024 AllianceGenome:RGD:1309611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent phospholipase A2 activity. Predicted to be involved in phosphatidylcholine metabolic process and phosphatidylglycerol metabolic process. Predicted to act upstream of or within low-density lipoprotein particle remodeling. Predicted to be located in extracellular region. Orthologous to human PLA2G2E (phospholipase A2 group IIE). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pla2g2e in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156404639..156410421)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151121363..151127147)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157327657..157333039)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IID Neighboring gene phospholipase A2, group V Neighboring gene phospholipase A2 group IIA Neighboring gene OTU deubiquitinase 3 Neighboring gene uncharacterized LOC134487023

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A(2) group IIE. Hou S, et al. Sci Rep, 2017 Sep 7. PMID 28883454, Free PMC Article
    2. The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. Sato H, et al. Cell Metab, 2014 Jul 1. PMID 24910243, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    group IIE secretory phospholipase A2
    NP_001406150.1
    XP_063143540.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419221.2 → NP_001406150.1  group IIE secretory phospholipase A2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      156404639..156410421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287470.1 → XP_063143540.1  group IIE secretory phospholipase A2 isoform X1

      Related
      ENSRNOP00000022847.6, ENSRNOT00000022847.7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106696.1: Suppressed sequence

      Description
      NM_001106696.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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