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    Nppb natriuretic peptide B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25105, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nppbprovided by RGD
    Official Full Name
    natriuretic peptide Bprovided by RGD
    Primary source
    RGD:3194
    See related
    EnsemblRapid:ENSRNOG00000008141 AllianceGenome:RGD:3194
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BNP; Bnf
    Summary
    Enables hormone activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cell population proliferation; and positive regulation of collecting lymphatic vessel constriction. Located in extracellular space and perinuclear region of cytoplasm. Used to study hypertension; hypertensive heart disease; myocardial infarction; polycystic kidney disease; and proteinuria. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); hyperhomocysteinemia; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1639.1) See more
    Orthologs
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    Genomic context

    See Nppb in Genome Data Viewer
    Location:
    5q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163699955..163701314)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158416813..158418175)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164796176..164797538)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 Neighboring gene RIKEN cDNA 2510039O18 gene like Neighboring gene natriuretic peptide A Neighboring gene chloride voltage-gated channel 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity  
    enables hormone activity PubMed 
    enables hormone activity  
    enables hormone receptor binding  
    enables hormone receptor binding  
    enables signaling receptor binding  
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in MAPK cascade  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in blood vessel diameter maintenance  
    involved_in cGMP biosynthetic process  
    acts_upstream_of cGMP biosynthetic process  
    involved_in cGMP-mediated signaling  
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress  
    involved_in cell growth involved in cardiac muscle cell development PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in coronary vasculature development  
    involved_in endothelial cell proliferation  
    involved_in heart development PubMed 
    involved_in homeostasis of number of cells  
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of cholangiocyte proliferation PubMed 
    involved_in negative regulation of smooth muscle cell proliferation PubMed 
    involved_in negative regulation of systemic arterial blood pressure  
    involved_in negative regulation of systemic arterial blood pressure PubMed 
    involved_in neuropeptide signaling pathway  
    involved_in positive regulation of cGMP-mediated signaling PubMed 
    involved_in positive regulation of collecting lymphatic vessel constriction PubMed 
    involved_in positive regulation of urine volume PubMed 
    involved_in protein folding  
    involved_in receptor guanylyl cyclase signaling pathway  
    involved_in receptor guanylyl cyclase signaling pathway  
    involved_in receptor guanylyl cyclase signaling pathway  
    involved_in response to 3-methylcholanthrene PubMed 
    involved_in response to calcium ion PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to nutrient levels  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to oxygen levels  
    involved_in response to peptide hormone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in signal transduction  
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    part_of protein-containing complex  

    General protein information

    Preferred Names
    natriuretic peptides B
    Names
    Brain natriuretic factor
    brain natriuretic factor prohormone
    brain natriuretic peptide
    gamma-brain natriuretic peptide
    iso-ANP
    natriuretic peptide precursor B
    natriuretic peptide precursor type B
    preproBNP
    proBNP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031545.1NP_113733.1  natriuretic peptides B precursor

      See identical proteins and their annotated locations for NP_113733.1

      Status: PROVISIONAL

      Source sequence(s)
      M25297
      UniProtKB/Swiss-Prot
      P13205
      UniProtKB/TrEMBL
      A6IU36
      Conserved Domains (1) summary
      pfam00212
      Location:85115
      ANP; Atrial natriuretic peptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      163699955..163701314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239376.2XP_006239438.1  natriuretic peptides B isoform X1

      Related
      ENSRNOP00000010778.4, ENSRNOT00000010779.7
      Conserved Domains (1) summary
      pfam00212
      Location:84114
      ANP; Atrial natriuretic peptide
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