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    Bag5 BAG cochaperone 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366734, updated on 9-Dec-2024

    Summary

    Symbol
    Bag5provided by RGD
    Full Name
    BAG cochaperone 5provided by RGD
    Primary source
    RGD:1310847
    See related
    EnsemblRapid:ENSRNOG00000058841 AllianceGenome:RGD:1310847
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bag5l1
    Summary
    Enables protein-folding chaperone binding activity and ubiquitin protein ligase binding activity. Involved in negative regulation of protein refolding; negative regulation of ubiquitin-protein transferase activity; and regulation of inclusion body assembly. Predicted to be located in inclusion body; mitochondrion; and perinuclear region of cytoplasm. Predicted to be part of junctional membrane complex. Predicted to be active in cytosol; membrane; and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2F. Orthologous to human BAG5 (BAG cochaperone 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 306.8), Brain (RPKM 70.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Bag5 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136589623..136593278, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130768467..130772122, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136180640..136185651, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 61A Neighboring gene transfer RNA leucine (anticodon AAG) Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene kinesin light chain 1 Neighboring gene uncharacterized LOC134479261

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC95040

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding PubMed 
    enables protein-folding chaperone binding  
    enables ubiquitin protein ligase binding PubMed 
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in Golgi organization  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of protein refolding PubMed 
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of protein ubiquitination PubMed 
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of ubiquitin-protein transferase activity PubMed 
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of inclusion body assembly  
    involved_in regulation of inclusion body assembly PubMed 
    involved_in regulation of inclusion body assembly  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in inclusion body  
    located_in inclusion body PubMed 
    part_of junctional membrane complex  
    part_of junctional membrane complex  
    is_active_in membrane  
    located_in mitochondrion  
    is_active_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm PubMed 

    General protein information

    Preferred Names
    BAG family molecular chaperone regulator 5
    Names
    BAG-5
    BCL2-associated athanogene 5
    BCL2-associated athanogene 5-like 1
    bcl-2-associated athanogene 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008526.2NP_001008526.1  BAG family molecular chaperone regulator 5

      See identical proteins and their annotated locations for NP_001008526.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088418
      UniProtKB/Swiss-Prot
      Q5QJC9
      UniProtKB/TrEMBL
      A6KBS7
      Related
      ENSRNOP00000100157.1, ENSRNOT00000132655.1
      Conserved Domains (1) summary
      smart00264
      Location:986
      BAG; BAG domains, present in regulator of Hsp70 proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      136589623..136593278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240601.4XP_006240663.1  BAG family molecular chaperone regulator 5 isoform X1

      See identical proteins and their annotated locations for XP_006240663.1

      UniProtKB/Swiss-Prot
      Q5QJC9
      UniProtKB/TrEMBL
      A6KBS7
      Related
      ENSRNOP00000071757.1, ENSRNOT00000085594.3
      Conserved Domains (1) summary
      smart00264
      Location:986
      BAG; BAG domains, present in regulator of Hsp70 proteins
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