Metap2 methionyl aminopeptidase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Metap2provided by RGD
Official Full Name: methionyl aminopeptidase 2provided by RGD
Primary source: RGD:70995
See related: EnsemblRapid:ENSRNOG00000021881 AllianceGenome:RGD:70995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p67; Amp2; Mnpep
Summary: Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in N-terminal protein amino acid modification; peptidyl-methionine modification; and protein processing. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 375.2), Muscle (RPKM 306.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (30299433..30327477, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (28412429..28440458, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (34762241..34789456, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ectopic expression of rat p67/MetAP2 in transformed cells can inhibit the tumorigenic phenotype by inhibiting the activation and activity of ERK1/2 MAP kinases and, thus, that p67/MetAP2 has tumor suppression activity.
Title: p67/MetAP2 suppresses K-RasV12-mediated transformation of NIH3T3 mouse fibroblasts in culture and in athymic mice.
Data suggest that methionine aminopeptidase 2 plays a role in the proliferation of fibroblasts and myofibroblasts in fibrotic lung diseases and may serve as a novel pharmacologic target in idiopathic pulmonary fibrosis.
Title: Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH126531 (e-PCR)
- UniSTS:209671

PMC280656P1 (e-PCR)
- UniSTS:272394

AW529792 (e-PCR)
- UniSTS:261244

RH135833 (e-PCR)
- UniSTS:209831

RH143662 (e-PCR)
- UniSTS:232908

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables aminopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables initiator methionyl aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloexopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloexopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloexopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid modification	ISO Inferred from Sequence Orthology more info
involved_in N-terminal protein amino acid modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-methionine modification	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-methionine modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: methionine aminopeptidase 2

Names: MAP 2; initiation factor 2 associated 67 kDa protein; initiation factor 2-associated 67 kDa glycoprotein; metAP 2; p67eIF2; peptidase M 2

NP_071984.2

EC 3.4.11.18

XP_038935781.1

EC 3.4.11.18

XP_038935782.1

EC 3.4.11.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022539.2 → NP_071984.2 methionine aminopeptidase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P38062

UniProtKB/TrEMBL

Q5BKA1

Related

ENSRNOP00000032680.7, ENSRNOT00000030056.8

Conserved Domains (1) summary

PTZ00053
Location:107 → 478

PTZ00053; methionine aminopeptidase 2; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

30299433..30327477 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079853.2 → XP_038935781.1 methionine aminopeptidase 2 isoform X1

UniProtKB/Swiss-Prot

P38062

Related

ENSRNOP00000087571.2, ENSRNOT00000110473.2

Conserved Domains (1) summary

PTZ00053
Location:106 → 477

PTZ00053; methionine aminopeptidase 2; Provisional
XM_039079854.2 → XP_038935782.1 methionine aminopeptidase 2 isoform X2

UniProtKB/Swiss-Prot

P38062

UniProtKB/TrEMBL

F7FJ19, Q6IRK1

Related

ENSRNOP00000030415.5, ENSRNOT00000031571.8

Conserved Domains (1) summary

PTZ00053
Location:71 → 442

PTZ00053; methionine aminopeptidase 2; Provisional