Pkdrej polycystin family receptor for egg jelly [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pkdrejprovided by RGD
Official Full Name: polycystin family receptor for egg jellyprovided by RGD
Primary source: RGD:1306587
See related: EnsemblRapid:ENSRNOG00000029591 AllianceGenome:RGD:1306587
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to act upstream of or within regulation of acrosome reaction. Predicted to be located in sperm plasma membrane. Predicted to be active in membrane. Orthologous to human PKDREJ (polycystin family receptor for egg jelly). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (118788939..118795313, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (116909094..116915468, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (126695498..126701872, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polycystin family receptor for egg jelly

Names: polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin); polycystic kidney disease and receptor for egg jelly-related protein; polycystin (PKD) family receptor for egg jelly

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134866.1 → NP_001128338.1 polycystin family receptor for egg jelly precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6HTF2, D3ZCW6

Related

ENSRNOP00000048039.2, ENSRNOT00000041057.5

Conserved Domains (3) summary

cd01752
Location:1111 → 1226

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam02010
Location:132 → 598

REJ; REJ domain

pfam08016
Location:1616 → 2046

PKD_channel; Polycystin cation channel