Ptma prothymosin alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptmaprovided by RGD
Official Full Name: prothymosin alphaprovided by RGD
Primary source: RGD:61829
See related: EnsemblRapid:ENSRNOG00000018584 AllianceGenome:RGD:61829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor binding activity; histone binding activity; and histone chaperone activity. Involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of NF-kappaB transcription factor activity; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human PTMA (prothymosin alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 5377.3), Lung (RPKM 2980.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (94624194..94628276)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (87176251..87180333)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (93545396..93549436)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The active core peptide sequence P30 (amino acids 49-78) of prothymosin alpha exerts its full survival effect in cultured cortical neurons against ischemic stress.
Title: Novel neuroprotective action of prothymosin α-derived peptide against retinal and brain ischemic damages.
PTMA is specifically localized in the acrosome of epididymal sperm
Title: First evidence of prothymosin α localization in the acrosome of mammalian male gametes.
results suggest necrosis-inducing stress induces an extacellular release of prothymosin-alpha in a non-vesicular manner; apoptosis-inducing stress does not, owing to loss of its interaction with S100A13, a cargo molecule for extracellular release
Title: Stress-induced non-vesicular release of prothymosin-α initiated by an interaction with S100A13, and its blockade by caspase-3 cleavage.
PTMA specific localization in the heads of spermatids and epididymal spermatozoa, associated with the acrosome system, supports for the first time the hypothesis of a direct function in male germ cells.
Title: Expression of prothymosin alpha in meiotic and post-meiotic germ cells during the first wave of rat spermatogenesis.
The differences in prothymosin alpha expression and localization during hepatocyte proliferation and apoptosis suggest that this protein may have a pleiotropic function.
Title: Apoptotic and proliferating hepatocytes differ in prothymosin alpha expression and cell localization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G42925 (e-PCR)
- UniSTS:94825

BE099527 (e-PCR)
- UniSTS:245692

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone chaperone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prothymosin alpha

Names: alpha-prothymosin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.