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    Apod apolipoprotein D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25239, updated on 9-Dec-2024

    Summary

    Official Symbol
    Apodprovided by RGD
    Official Full Name
    apolipoprotein Dprovided by RGD
    Primary source
    RGD:2137
    See related
    EnsemblRapid:ENSRNOG00000048273 AllianceGenome:RGD:2137
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AOPDGN
    Summary
    Predicted to enable cholesterol binding activity. Involved in peripheral nervous system axon regeneration; response to xenobiotic stimulus; and tissue regeneration. Located in cytosolic ribosome; dendrite; and neuronal cell body. Biomarker of status epilepticus and vasculogenic impotence. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 625.1) and Muscle (RPKM 86.9) See more
    Orthologs
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    Genomic context

    See Apod in Genome Data Viewer
    Location:
    11q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (82936216..82957264)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (69431261..69452306)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (72705204..72726263)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene 3-hydroxybutyrate dehydrogenase 1 Neighboring gene uncharacterized LOC134481093 Neighboring gene uncharacterized LOC134481094 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 2, pseudogene 3 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2 Neighboring gene uncharacterized LOC134481096

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding  
    enables cholesterol binding  
    enables cholesterol binding  
    enables lipid binding  
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    involved_in brain development  
    involved_in glucose metabolic process  
    involved_in glucose metabolic process  
    involved_in lipid metabolic process  
    involved_in lipid metabolic process  
    involved_in lipid metabolic process  
    involved_in lipid transport  
    involved_in negative regulation of T cell migration  
    involved_in negative regulation of T cell migration  
    involved_in negative regulation of cytokine production involved in inflammatory response  
    involved_in negative regulation of cytokine production involved in inflammatory response  
    involved_in negative regulation of focal adhesion assembly  
    involved_in negative regulation of focal adhesion assembly  
    involved_in negative regulation of lipoprotein lipid oxidation  
    involved_in negative regulation of lipoprotein lipid oxidation  
    involved_in negative regulation of lipoprotein lipid oxidation  
    involved_in negative regulation of monocyte chemotactic protein-1 production  
    involved_in negative regulation of monocyte chemotactic protein-1 production  
    involved_in negative regulation of platelet-derived growth factor receptor signaling pathway  
    involved_in negative regulation of platelet-derived growth factor receptor signaling pathway  
    involved_in negative regulation of protein import into nucleus  
    involved_in negative regulation of protein import into nucleus  
    involved_in negative regulation of smooth muscle cell proliferation  
    involved_in negative regulation of smooth muscle cell proliferation  
    involved_in negative regulation of smooth muscle cell-matrix adhesion  
    involved_in negative regulation of smooth muscle cell-matrix adhesion  
    involved_in peripheral nervous system axon regeneration PubMed 
    involved_in response to axon injury PubMed 
    involved_in response to reactive oxygen species  
    involved_in response to reactive oxygen species  
    involved_in response to reactive oxygen species  
    involved_in response to reactive oxygen species  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in tissue regeneration  
    involved_in tissue regeneration PubMed 
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosolic ribosome PubMed 
    located_in dendrite PubMed 
    located_in extracellular region  
    located_in extracellular space  
    located_in extracellular space  
    located_in neuronal cell body PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    apolipoprotein D
    Names
    apo-D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012777.2NP_036909.2  apolipoprotein D precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P23593
      UniProtKB/TrEMBL
      A6IRW8, M0R4S2
      Related
      ENSRNOP00000064368.1, ENSRNOT00000073330.4
      Conserved Domains (1) summary
      cd19437
      Location:25182
      lipocalin_apoD-like; apolipoprotein D and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      82936216..82957264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087998.2XP_038943926.1  apolipoprotein D isoform X1

      UniProtKB/Swiss-Prot
      P23593
      UniProtKB/TrEMBL
      A6IRW7
      Related
      ENSRNOP00000100734.1, ENSRNOT00000144387.1
      Conserved Domains (1) summary
      cd19437
      Location:40197
      lipocalin_apoD-like; apolipoprotein D and similar proteins
    2. XM_039087999.2XP_038943927.1  apolipoprotein D isoform X1

      UniProtKB/Swiss-Prot
      P23593
      UniProtKB/TrEMBL
      A6IRW7
      Conserved Domains (1) summary
      cd19437
      Location:40197
      lipocalin_apoD-like; apolipoprotein D and similar proteins
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