Ch25h cholesterol 25-hydroxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ch25hprovided by RGD
Official Full Name: cholesterol 25-hydroxylaseprovided by RGD
Primary source: RGD:1310575
See related: EnsemblRapid:ENSRNOG00000019141 AllianceGenome:RGD:1310575
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable C-4 methylsterol oxidase activity and cholesterol 25-hydroxylase activity. Predicted to be involved in several processes, including B cell chemotaxis; negative regulation of fusion of virus membrane with host plasma membrane; and sterol metabolic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human CH25H (cholesterol 25-hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 16.2), Lung (RPKM 13.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (241428048..241429366, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (232014877..232016195, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (252807062..252811409, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H.
Title: Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-4 methylsterol oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol 25-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables cholesterol 25-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables steroid hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in B cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fusion of virus membrane with host plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fusion of virus membrane with host plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to type I interferon	ISO Inferred from Sequence Orthology more info
involved_in response to type I interferon	ISS Inferred from Sequence or Structural Similarity more info
involved_in sterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cholesterol 25-hydroxylase

Names: cholesterol 25-monooxygenase

NP_001020586.1

EC 1.14.99.38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.