Abcf1 ATP binding cassette subfamily F member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcf1provided by RGD
Official Full Name: ATP binding cassette subfamily F member 1provided by RGD
Primary source: RGD:620286
See related: EnsemblRapid:ENSRNOG00000000799 AllianceGenome:RGD:620286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Abc50
Summary: Predicted to enable ATP binding activity; ribosome binding activity; and translation activator activity. Predicted to be involved in positive regulation of translation and translational initiation. Located in ribosome. Orthologous to human ABCF1 (ATP binding cassette subfamily F member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 206.0), Thymus (RPKM 159.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (2807315..2820240)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (2802519..2815433)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (3309914..3322828)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH128459 (e-PCR)
- UniSTS:211767

D20Yum34 (e-PCR)
- UniSTS:526145

RH140082 (e-PCR)
- UniSTS:222163

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation activator activity	ISO Inferred from Sequence Orthology more info
enables translation activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in ribosome biogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in ribosome biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	NAS Non-traceable Author Statement more info	PubMed
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-binding cassette sub-family F member 1

Names: ATP-binding cassette 50; ATP-binding cassette, sub-family F (GCN20), member 1; ATP-binding cassette, subfamily F (GCN20), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109883.2 → NP_001103353.1 ATP-binding cassette sub-family F member 1

See identical proteins and their annotated locations for NP_001103353.1

Status: VALIDATED

Source sequence(s)

BP495802, BX883048, CB801303, CK356298, CV114142, EV771702, EV773343

UniProtKB/Swiss-Prot

Q6MG08, Q9ERQ2

UniProtKB/TrEMBL

A0A8L2PZQ3, A6KT63

Related

ENSRNOP00000001049.9, ENSRNOT00000001049.10

Conserved Domains (2) summary

cd03221
Location:298 → 519

ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F

COG0488
Location:296 → 827

Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]