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    Zfp248 zinc finger protein 248 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp248provided by RGD
    Official Full Name
    zinc finger protein 248provided by RGD
    Primary source
    RGD:1561270
    See related
    EnsemblRapid:ENSRNOG00000037251 AllianceGenome:RGD:1561270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf248; RGD1561270
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF248 (zinc finger protein 248). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 24.3), Adrenal (RPKM 15.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp248 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (153277735..153302545, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (151605433..151630249, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II, I and III subunit L, pseudogene 2 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene BMS1 ribosome biogenesis factor Neighboring gene uncharacterized LOC134486626 Neighboring gene U4 spliceosomal RNA Neighboring gene zinc finger protein 9 Neighboring gene ankyrin repeat domain containing 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 248

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427587.2 → NP_001414516.1  zinc finger protein 248

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A096MJS0, F1LTY6
      Related
      ENSRNOP00000068443.3, ENSRNOT00000076307.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      153277735..153302545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108794.2 → XP_038964722.1  zinc finger protein 248 isoform X1

      UniProtKB/TrEMBL
      A0A096MJS0, F1LTY6
      Conserved Domains (6) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:403 → 469
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:491 → 511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:242 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:489 → 511
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:531 → 556
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039108792.2 → XP_038964720.1  zinc finger protein 248 isoform X1

      UniProtKB/TrEMBL
      A0A096MJS0, F1LTY6
      Conserved Domains (6) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:403 → 469
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:491 → 511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:242 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:489 → 511
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:531 → 556
      zf-H2C2_2; Zinc-finger double domain

    3. XM_039108796.2 → XP_038964724.1  zinc finger protein 248 isoform X2

      UniProtKB/TrEMBL
      A0A096MKA8, A0A8J8XWU2, A6IL63
      Conserved Domains (5) summary
      COG5048
      Location:302 → 368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390 → 410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:141 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:388 → 410
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:430 → 455
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039108795.2 → XP_038964723.1  zinc finger protein 248 isoform X2

      UniProtKB/TrEMBL
      A0A096MKA8, A0A8J8XWU2, A6IL63
      Conserved Domains (5) summary
      COG5048
      Location:302 → 368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390 → 410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:141 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:388 → 410
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:430 → 455
      zf-H2C2_2; Zinc-finger double domain

    5. XM_039108797.2 → XP_038964725.1  zinc finger protein 248 isoform X2

      UniProtKB/TrEMBL
      A0A096MKA8, A0A8J8XWU2, A6IL63
      Conserved Domains (5) summary
      COG5048
      Location:302 → 368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390 → 410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:141 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:388 → 410
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:430 → 455
      zf-H2C2_2; Zinc-finger double domain

    6. XM_039108798.2 → XP_038964726.1  zinc finger protein 248 isoform X2

      UniProtKB/TrEMBL
      A0A096MKA8, A0A8J8XWU2, A6IL63
      Conserved Domains (5) summary
      COG5048
      Location:302 → 368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390 → 410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:141 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:388 → 410
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:430 → 455
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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