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    Socs5 suppressor of cytokine signaling 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500616, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Socs5provided by RGD
    Official Full Name
    suppressor of cytokine signaling 5provided by RGD
    Primary source
    RGD:1564914
    See related
    EnsemblRapid:ENSRNOG00000028504 AllianceGenome:RGD:1564914
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564914
    Summary
    Predicted to enable epidermal growth factor receptor binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including cellular response to low-density lipoprotein particle stimulus; regulation of T-helper cell differentiation; and regulation of macromolecule metabolic process. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Orthologous to human SOCS5 (suppressor of cytokine signaling 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 134.4), Kidney (RPKM 114.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Socs5 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (13235157..13266161, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (7481039..7512644, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (10671311..10705610)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103467 Neighboring gene uncharacterized LOC134479309 Neighboring gene uncharacterized LOC134479310 Neighboring gene karyopherin subunit alpha 2 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes. Hwang MN, et al. Mol Cells, 2007 Feb 28. PMID 17464217
    2. [Expression of suppressor of cytokine signaling in retina of experimental autoimmune uveoretinitis]. Wang H, et al. Zhonghua Yan Ke Za Zhi, 2008 Oct. PMID 19176113
    3. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. Kario E, et al. J Biol Chem, 2005 Feb 25. PMID 15590694
    4. Inhibitors of cytokine signal transduction. Wormald S, et al. J Biol Chem, 2004 Jan 9. PMID 14607831
    5. Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Nicholson SE, et al. Proc Natl Acad Sci U S A, 2005 Feb 15. PMID 15695332, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that activated Stat3 binds to SOCS promoters and leads to their transcriptional induction.
      Title: PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes.
    2. Up-regulation of SOCS5 may have protective functions in experimental autoimmune uveoretinitis.
      Title: [Expression of suppressor of cytokine signaling in retina of experimental autoimmune uveoretinitis].
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of T-helper 2 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of T-helper 1 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vascular endothelial cell response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109274.1 → NP_001102744.1  suppressor of cytokine signaling 5

      See identical proteins and their annotated locations for NP_001102744.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6H9E6, D3ZUE4
      Related
      ENSRNOP00000110665.1, ENSRNOT00000134939.1
      Conserved Domains (3) summary
      cd03739
      Location:479 → 534
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:146 → 195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:370 → 470
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      13235157..13266161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239718.5 → XP_006239780.1  suppressor of cytokine signaling 5 isoform X1

      See identical proteins and their annotated locations for XP_006239780.1

      UniProtKB/TrEMBL
      A6H9E6, D3ZUE4
      Related
      ENSRNOP00000084063.1, ENSRNOT00000094405.2
      Conserved Domains (3) summary
      cd03739
      Location:479 → 534
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:146 → 195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:370 → 470
      SH2; Src homology 2 (SH2) domain

    2. XM_063262285.1 → XP_063118355.1  suppressor of cytokine signaling 5 isoform X1

      UniProtKB/TrEMBL
      A6H9E6, D3ZUE4

    3. XM_063262286.1 → XP_063118356.1  suppressor of cytokine signaling 5 isoform X1

      UniProtKB/TrEMBL
      A6H9E6, D3ZUE4
    Nucleotide Protein Strain
    Heading Accession and Version

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