Scgn secretagogin, EF-hand calcium binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scgnprovided by RGD
Official Full Name: secretagogin, EF-hand calcium binding proteinprovided by RGD
Primary source: RGD:1303281
See related: EnsemblRapid:ENSRNOG00000016628 AllianceGenome:RGD:1303281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Predicted to be located in extracellular region and transport vesicle membrane. Predicted to be active in several cellular components, including cytosol; dendrite; and terminal bouton. Orthologous to human SCGN (secretagogin, EF-hand calcium binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 22.0), Liver (RPKM 3.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (41534558..41576525)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (41106681..41148656)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (43357888..43399321)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice.
Title: Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice.
Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration.
Title: Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.
secretagogin, characterizes novel groups of interneurons in the rat striatum
Title: Calcium-binding protein, secretagogin, characterizes novel groups of interneurons in the rat striatum.
Scgn is a CaBP expressed in a subpopulation of nociceptive DRG neurons and their processes in the dorsal horn.
Title: Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human.
There is an association of TAU and the calcium-binding protein SCGN in insulin-secreting cells implicating beta-cells as an extra cerebral site of tauopathy.
Title: Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin.
The sequence homology and the comparable tissue expression patterns of human and rat secretagogin indicate conserved intracellular functions.
Title: New functional aspects of the neuroendocrine marker secretagogin based on the characterization of its rat homolog.
Characterization of the human secretagogin homolog.
Title: Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secretagogin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.