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    Shroom2 shroom family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317435, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Shroom2provided by RGD
    Official Full Name
    shroom family member 2provided by RGD
    Primary source
    RGD:1565163
    See related
    EnsemblRapid:ENSRNOG00000024322 AllianceGenome:RGD:1565163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Apxl; Ab2-404
    Summary
    Predicted to enable actin filament binding activity; beta-catenin binding activity; and protein domain specific binding activity. Predicted to be involved in actin filament organization; cell migration; and melanosome organization. Predicted to act upstream of or within cell-cell junction maintenance and negative regulation of actin filament depolymerization. Predicted to be located in several cellular components, including bicellular tight junction; cell cortex; and neuronal cell body. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Orthologous to human SHROOM2 (shroom family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 89.7), Brain (RPKM 76.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Shroom2 in Genome Data Viewer
    Location:
    Xq13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (25308163..25480194, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (21812469..21983724, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (23478869..23649424, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RAB7A, member RAS oncogene family, pseudogene 1 Neighboring gene spermatogenesis associated multipass transmembrane protein 2 like 3 Neighboring gene G protein-coupled receptor 143 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium. Fairbank PD, et al. Development, 2006 Oct. PMID 16987870
    2. Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. Dietz ML, et al. J Biol Chem, 2006 Jul 21. PMID 16684770
    3. Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions. Etournay R, et al. J Cell Sci, 2007 Aug 15. PMID 17666436
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization and functional analysis of the mouse Shroom2 ortholog.
      Title: Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell-cell junction maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein Shroom2
    Names
    apical protein-like
    liver regeneration-related protein LRRG167
    protein Apxl

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047893.4 → NP_001041358.2  protein Shroom2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A0R5, D4A053
      Related
      ENSRNOP00000105757.1, ENSRNOT00000122384.1
      Conserved Domains (3) summary
      cd00992
      Location:24 → 105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08687
      Location:1196 → 1484
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:665 → 839
      ASD1; Apx/Shroom domain ASD1

    2. NM_001434184.1 → NP_001421113.1  protein Shroom2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    3. NM_001434185.1 → NP_001421114.1  protein Shroom2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A0R5

    4. NM_001434186.1 → NP_001421115.1  protein Shroom2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A0R5

    5. NM_001434187.1 → NP_001421116.1  protein Shroom2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    6. NM_001434188.1 → NP_001421117.1  protein Shroom2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    7. NM_001434189.1 → NP_001421118.1  protein Shroom2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    8. NM_001434190.1 → NP_001421119.1  protein Shroom2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      25308163..25480194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256817.4 → XP_006256879.1  protein Shroom2 isoform X2

      Conserved Domains (3) summary
      cd00992
      Location:24 → 105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08687
      Location:1190 → 1478
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:665 → 839
      ASD1; Apx/Shroom domain ASD1

    2. XM_006256816.5 → XP_006256878.1  protein Shroom2 isoform X1

      Conserved Domains (3) summary
      cd00992
      Location:24 → 105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08687
      Location:1191 → 1479
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:665 → 839
      ASD1; Apx/Shroom domain ASD1

    3. XM_008773126.4 → XP_008771348.1  protein Shroom2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A0R5
      Related
      ENSRNOP00000083830.2, ENSRNOT00000104025.2
      Conserved Domains (3) summary
      cd00992
      Location:24 → 105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08687
      Location:1152 → 1440
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:621 → 795
      ASD1; Apx/Shroom domain ASD1

    4. XM_008773129.4 → XP_008771351.1  protein Shroom2 isoform X4

      Conserved Domains (1) summary
      pfam08687
      Location:151 → 439
      ASD2; Apx/Shroom domain ASD2

    5. XM_008773130.4 → XP_008771352.1  protein Shroom2 isoform X4

      Conserved Domains (1) summary
      pfam08687
      Location:151 → 439
      ASD2; Apx/Shroom domain ASD2

    6. XM_008773128.4 → XP_008771350.1  protein Shroom2 isoform X4

      Conserved Domains (1) summary
      pfam08687
      Location:151 → 439
      ASD2; Apx/Shroom domain ASD2

    7. XM_008773131.3 → XP_008771353.1  protein Shroom2 isoform X4

      Conserved Domains (1) summary
      pfam08687
      Location:151 → 439
      ASD2; Apx/Shroom domain ASD2

    8. XM_008773127.4 → XP_008771349.1  protein Shroom2 isoform X4

      Conserved Domains (1) summary
      pfam08687
      Location:151 → 439
      ASD2; Apx/Shroom domain ASD2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138859.1: Suppressed sequence

      Description
      NM_138859.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TP36.1 GenPept UniProtKB/Swiss-Prot:Q7TP36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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