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    Pithd1 PITH domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pithd1provided by RGD
    Official Full Name
    PITH domain containing 1provided by RGD
    Primary source
    RGD:1308048
    See related
    EnsemblRapid:ENSRNOG00000010873 AllianceGenome:RGD:1308048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308048
    Summary
    Predicted to be involved in positive regulation of DNA-templated transcription and positive regulation of megakaryocyte differentiation. Predicted to act upstream of or within several processes, including penetration of cumulus oophorus; penetration of zona pellucida; and regulation of proteasomal protein catabolic process. Predicted to be located in sperm cytoplasmic droplet. Orthologous to human PITHD1 (PITH domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 513.0), Brain (RPKM 334.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pithd1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153489529..153500025, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148205995..148216490, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154322562..154333080, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene UDP-galactose-4-epimerase Neighboring gene lysophospholipase 2 Neighboring gene elongin A Neighboring gene uncharacterized LOC134487012 Neighboring gene ribosomal protein L11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation. Lu B, et al. Cell Mol Life Sci, 2015 Feb. PMID 25134913, Free PMC Article
    2. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within penetration of cumulus oophorus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within penetration of zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm cytoplasmic droplet ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PITH domain-containing protein 1
    Names
    PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399521.1 → NP_001386450.1  PITH domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IT90, A6IT92
      Related
      ENSRNOP00000093205.1, ENSRNOT00000119023.2
      Conserved Domains (1) summary
      pfam06201
      Location:35 → 175
      PITH; PITH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153489529..153500025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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