Alpk2 alpha-kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alpk2provided by RGD
Official Full Name: alpha-kinase 2provided by RGD
Primary source: RGD:1564431
See related: EnsemblRapid:ENSRNOG00000017421 AllianceGenome:RGD:1564431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564431
Summary: Predicted to be involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Predicted to act upstream of or within regulation of gene expression. Predicted to be located in basolateral plasma membrane. Orthologous to human ALPK2 (alpha kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 366.7), Muscle (RPKM 153.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (61045717..61161703, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (58775603..58906150, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (60960009..61072116, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU049015 (e-PCR)
- UniSTS:145463

STS-X52486 (e-PCR)
- UniSTS:79936

RH134129 (e-PCR)
- UniSTS:217411

D18Rat61 (e-PCR)
- UniSTS:118470

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in epicardium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway involved in heart development	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-kinase 2; alpha-protein kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.