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    Map2k6 mitogen-activated protein kinase kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114495, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Map2k6provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase 6provided by RGD
    Primary source
    RGD:620666
    See related
    EnsemblRapid:ENSRNOG00000004437 AllianceGenome:RGD:620666
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mkk6
    Summary
    Enables MAP kinase kinase activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 174.7), Thymus (RPKM 86.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map2k6 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95872747..95987747)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (95373304..95490406)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (98707160..98823054)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 6 Neighboring gene ATP binding cassette subfamily A member 5 Neighboring gene uncharacterized LOC102551705 Neighboring gene uncharacterized LOC108352228

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of mitogen-activated protein kinase-activated kinases-2 and -3 (MAPKAPK-2/-3) in vivo during corpus luteum formation in the rat. Maizels ET, et al. Mol Endocrinol, 2001 May. PMID 11328854
    2. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau. Hartzler AW, et al. Neurobiol Aging, 2002 Sep-Oct. PMID 12392790
    3. The MKK6-p38 MAPK pathway prolongs the cardiac contractile calcium transient, downregulates SERCA2, and activates NF-AT. Andrews C, et al. Cardiovasc Res, 2003 Jul 1. PMID 12829175
    4. MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo. Degousee N, et al. Circ Res, 2003 Apr 18. PMID 12649265
    5. Different effects of amlodipine and enalapril on the mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-extracellular signal-regulated kinase pathway for induction of vascular smooth muscle cell differentiation in vivo. Umemoto S, et al. Hypertens Res, 2006 Mar. PMID 16755153

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serine phosphorylation of p66shc is carried out by active MKK6. beta-Amyloid-induced ROS production and apoptosis increased in the presence of MKK6 and p66shc, which directly associate.
      Title: β-Amyloid-evoked apoptotic cell death is mediated through MKK6-p66shc pathway.
    2. The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1, and suggested that the order of phosphorylation is dictated by both binding and catalysis rates.
      Title: Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascade.
    3. Rap1, MKK3/6, and p38 MAPK have a role in the induction of mGluR-dependent LTD by directly coupling to receptor trafficking machineries to facilitate the loss of synaptic AMPA receptors
      Title: Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93287

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to sorbitol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ovulation cycle process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of prostaglandin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ischemia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 6
    NP_446155.1
    XP_038940961.1
    XP_038940962.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053703.3 → NP_446155.1  dual specificity mitogen-activated protein kinase kinase 6

      See identical proteins and their annotated locations for NP_446155.1

      Status: PROVISIONAL

      Source sequence(s)
      AF369384
      UniProtKB/TrEMBL
      A6HKD4, F7EK55, Q925D6
      Related
      ENSRNOP00000006217.3, ENSRNOT00000006217.8
      Conserved Domains (1) summary
      cd06617
      Location:51 → 333
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      95872747..95987747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085034.2 → XP_038940962.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

      UniProtKB/TrEMBL
      A6HKD7
      Conserved Domains (1) summary
      cd06617
      Location:1 → 264
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

    2. XM_039085033.2 → XP_038940961.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

      UniProtKB/TrEMBL
      A6HKD7
      Conserved Domains (1) summary
      cd06617
      Location:1 → 264
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    Nucleotide Protein Strain
    Heading Accession and Version

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