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    Npw neuropeptide W [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259224, updated on 9-Dec-2024

    Summary

    Official Symbol
    Npwprovided by RGD
    Official Full Name
    neuropeptide Wprovided by RGD
    Primary source
    RGD:727858
    See related
    EnsemblRapid:ENSRNOG00000012390 AllianceGenome:RGD:727858
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables G protein-coupled receptor binding activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in extracellular region. Orthologous to human NPW (neuropeptide W). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 150.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Npw in Genome Data Viewer
    Location:
    10q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14184819..14186155, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13680275..13681618, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14021187..14022452, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nth-like DNA glycosylase 1 Neighboring gene NHERF family PDZ scaffold protein 2 Neighboring gene zinc finger protein 598 Neighboring gene synaptogyrin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in feeding behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuropeptide W
    Names
    PPL8
    prepro-Neuropeptide W polypeptide
    preproprotein L8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153294.1NP_695206.1  neuropeptide W precursor

      See identical proteins and their annotated locations for NP_695206.1

      Status: PROVISIONAL

      Source sequence(s)
      AB084278
      UniProtKB/Swiss-Prot
      Q8K1M5
      UniProtKB/TrEMBL
      A6HCU9
      Related
      ENSRNOP00000016554.1, ENSRNOT00000016554.4
      Conserved Domains (1) summary
      pfam15180
      Location:39145
      NPBW; Neuropeptides B and W

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14184819..14186155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085300.2XP_038941228.1  neuropeptide W isoform X1

      UniProtKB/TrEMBL
      A6HCU8