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    Oasl 2'-5'-oligoadenylate synthetase-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oaslprovided by RGD
    Official Full Name
    2'-5'-oligoadenylate synthetase-likeprovided by RGD
    Primary source
    RGD:1308586
    See related
    EnsemblRapid:ENSRNOG00000001187 AllianceGenome:RGD:1308586
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oasl1
    Summary
    Predicted to enable DNA binding activity and double-stranded RNA binding activity. Predicted to be involved in several processes, including innate immune response; interleukin-27-mediated signaling pathway; and positive regulation of RIG-I signaling pathway. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OASL (2'-5'-oligoadenylate synthetase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 77.9), Spleen (RPKM 54.0) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Oasl in Genome Data Viewer
    Location:
    12q16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47343551..47356509, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41682900..41695641, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47444138..47456680, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene signal peptide peptidase like 3 Neighboring gene HNF1 homeobox A Neighboring gene similar to human chromosome 12 open reading frame 43 Neighboring gene uncharacterized LOC134481304 Neighboring gene uncharacterized LOC120096007 Neighboring gene RIKEN cDNA 4930519G04 gene like Neighboring gene 2'-5' oligoadenylate synthetase-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. 2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro. Ishibashi M, et al. Biochem Biophys Res Commun, 2010 Feb 12. PMID 20074559
    2. Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase. Rebouillat D, et al. Eur J Biochem, 1998 Oct 15. PMID 9826176
    3. The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain. Marques J, et al. J Gen Virol, 2008 Nov. PMID 18931074
    4. Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family. Eskildsen S, et al. Nucleic Acids Res, 2003 Jun 15. PMID 12799444, Free PMC Article
    5. Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. Kakuta S, et al. J Interferon Cytokine Res, 2002 Sep. PMID 12396720

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 2'-5'-oligoadenylate synthetase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables 2'-5'-oligoadenylate synthetase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    2'-5'-oligoadenylate synthase-like protein 1
    Names
    2'-5' oligoadenylate synthetase-like 1
    59 kDa 2'-5'-oligoadenylate synthase-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009681.1 → NP_001009681.1  2'-5'-oligoadenylate synthase-like protein 1

      See identical proteins and their annotated locations for NP_001009681.1

      Status: PROVISIONAL

      Source sequence(s)
      AY227756
      UniProtKB/Swiss-Prot
      G3V645, Q5MYW3
      Related
      ENSRNOP00000001570.4, ENSRNOT00000001570.6
      Conserved Domains (5) summary
      cd05400
      Location:29 → 209
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      smart00213
      Location:431 → 499
      UBQ; Ubiquitin homologues
      pfam00240
      Location:436 → 502
      ubiquitin; Ubiquitin family
      pfam10421
      Location:167 → 347
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl00155
      Location:351 → 430
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      47343551..47356509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271353.1 → XP_063127423.1  2'-5'-oligoadenylate synthase-like protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3V645.1 GenPept UniProtKB/Swiss-Prot:G3V645

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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