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    Psd2 pleckstrin and Sec7 domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psd2provided by RGD
    Official Full Name
    pleckstrin and Sec7 domain containing 2provided by RGD
    Primary source
    RGD:1311075
    See related
    EnsemblRapid:ENSRNOG00000019177 AllianceGenome:RGD:1311075
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in several cellular components, including cleavage furrow; neuronal cell body; and ruffle membrane. Predicted to be active in glutamatergic synapse and postsynapse. Orthologous to human PSD2 (pleckstrin and Sec7 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 63.0) and Kidney (RPKM 2.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psd2 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27838943..27890712)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27564912..27616674)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28781267..28832429)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551758 Neighboring gene uncharacterized LOC134483009 Neighboring gene neuregulin 2 Neighboring gene uncharacterized LOC120098187 Neighboring gene purine rich element binding protein A Neighboring gene IgA-inducing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells. Matsuya S, et al. J Neurochem, 2005 May. PMID 15836626
    2. EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. Ueda T, et al. FEBS Lett, 2013 Jun 5. PMID 23603394

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PH and SEC7 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107395.1 → NP_001100865.1  PH and SEC7 domain-containing protein 2

      See identical proteins and their annotated locations for NP_001100865.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473974
      UniProtKB/TrEMBL
      A6J301
      Related
      ENSRNOP00000026112.6, ENSRNOT00000026112.7
      Conserved Domains (3) summary
      cd00171
      Location:295 → 462
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:508 → 631
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:528 → 623
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      27838943..27890712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277371.1 → XP_063133441.1  PH and SEC7 domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6J301

    2. XM_039096865.2 → XP_038952793.1  PH and SEC7 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      D4ACB6
      Conserved Domains (2) summary
      cd00171
      Location:295 → 463
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:509 → 632
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    3. XM_039096866.2 → XP_038952794.1  PH and SEC7 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      D4ACB6
      Conserved Domains (2) summary
      cd00171
      Location:295 → 463
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:509 → 632
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    RNA

    1. XR_005496039.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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