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    Cryge crystallin, gamma E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24279, updated on 9-Dec-2024

    Summary

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    Symbol
    Crygeprovided by RGD
    Full Name
    crystallin, gamma Eprovided by RGD
    Primary source
    RGD:2423
    See related
    AllianceGenome:RGD:2423
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Len; Cryg5
    Summary
    Predicted to be a structural constituent of eye lens. Involved in lens development in camera-type eye. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Cryge in Genome Data Viewer
    Location:
    9q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (73923661..73926258, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (66429924..66432521, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71764317..71767045, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene basic proline-rich protein-like Neighboring gene frizzled class receptor 5 Neighboring gene pleckstrin homology domain containing M3 Neighboring gene uncharacterized LOC120094696 Neighboring gene uncharacterized LOC102552040 Neighboring gene crystallin, gamma D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Strict co-linearity of genetic and protein folding domains in an intragenically duplicated rat lens gamma-crystallin gene. Moormann RJ, et al. J Mol Biol, 1983 Dec 25. PMID 6319707
    2. Consensus sequences of the Rattus norvegicus B1- and B2 repeats. den Dunnen JT, et al. Nucleic Acids Res, 1987 Mar 25. PMID 3562235, Free PMC Article
    3. Site specific oxidation of amino acid residues in rat lens γ-crystallin induced by low-dose γ-irradiation. Kim I, et al. Biochem Biophys Res Commun, 2015 Oct 30. PMID 26385181
    4. Towards a molecular understanding of phase separation in the lens: a comparison of the X-ray structures of two high Tc gamma-crystallins, gammaE and gammaF, with two low Tc gamma-crystallins, gammaB and gammaD. Norledge BV, et al. Exp Eye Res, 1997 Nov. PMID 9367641
    5. Extensive intragenic sequence homology in two distinct rat lens gamma-crystallin cDNAs suggests duplications of a primordial gene. Moormann RJ, et al. Proc Natl Acad Sci U S A, 1982 Nov. PMID 6294661, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of eye lens TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lens development in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-crystallin E
    Names
    Crystallin, gamma polypeptide 5
    gamma-2
    gamma-E-crystallin
    gamma-crystallin 3-1
    gamma-crystallin D-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173289.1 → NP_775411.1  gamma-crystallin E

      See identical proteins and their annotated locations for NP_775411.1

      Status: PROVISIONAL

      Source sequence(s)
      M19359
      UniProtKB/Swiss-Prot
      P02528
      UniProtKB/TrEMBL
      D3ZR45
      Conserved Domains (2) summary
      smart00247
      Location:3 → 82
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:89 → 170
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      73923661..73926258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02528.2 GenPept UniProtKB/Swiss-Prot:P02528

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