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    Ppp1cc protein phosphatase 1 catalytic subunit gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24669, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppp1ccprovided by RGD
    Official Full Name
    protein phosphatase 1 catalytic subunit gammaprovided by RGD
    Primary source
    RGD:3377
    See related
    EnsemblRapid:ENSRNOG00000001269 AllianceGenome:RGD:3377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PP-1G; Ppp1cc1
    Summary
    Enables lamin binding activity; protein domain specific binding activity; and protein phosphatase 1 binding activity. Involved in positive regulation of glial cell proliferation. Acts upstream of or within neuron differentiation. Located in dendritic spine. Is active in glutamatergic synapse; postsynapse; and presynapse. Biomarker of congestive heart failure. Orthologous to human PPP1CC (protein phosphatase 1 catalytic subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 699.2), Kidney (RPKM 698.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ppp1cc in Genome Data Viewer
    Location:
    12q16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40043822..40061301, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34383072..34400553, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39864302..39882030, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352448 Neighboring gene protein phosphatase targeting COQ7 Neighboring gene tectonic family member 1 Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene uncharacterized LOC120095977 Neighboring gene coiled-coil domain containing 63 Neighboring gene 5S ribosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables histone H2AXS140 phosphatase activity  
    enables lamin binding PubMed 
    enables metal ion binding  
    enables myosin phosphatase activity  
    enables phosphatase activity  
    enables phosphatase activity  
    enables phosphoprotein phosphatase activity  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein kinase binding  
    enables protein phosphatase 1 binding PubMed 
    enables protein phosphatase binding PubMed 
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein-containing complex binding PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development  
    involved_in cell division  
    involved_in chromatin remodeling  
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in entrainment of circadian clock by photoperiod  
    involved_in entrainment of circadian clock by photoperiod  
    involved_in glycogen metabolic process  
    acts_upstream_of_or_within neuron differentiation PubMed 
    involved_in positive regulation of glial cell proliferation PubMed 
    acts_upstream_of_or_within protein dephosphorylation  
    involved_in protein dephosphorylation  
    involved_in protein dephosphorylation  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    acts_upstream_of_or_within regulation of nucleocytoplasmic transport  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in rhythmic process  
    acts_upstream_of_or_within spermatogenesis  
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex  
    part_of PTW/PP1 phosphatase complex  
    located_in chromosome, telomeric region  
    located_in cleavage furrow  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in dendritic spine PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in kinetochore  
    located_in microtubule organizing center  
    located_in midbody  
    located_in mitochondrial outer membrane  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nuclear speck  
    located_in nucleolus  
    located_in nucleolus  
    is_active_in nucleus  
    located_in nucleus  
    is_active_in postsynapse PubMed 
    is_active_in presynapse PubMed 
    part_of protein-containing complex  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase PP1-gamma catalytic subunit
    Names
    protein phosphatase 1, catalytic subunit, gamma isozyme
    protein phosphatase 1C catalytic subunit
    protein serine-threonine phosphatase catalytic subunit PP-1b
    NP_001257912.1
    NP_071943.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270983.1NP_001257912.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2

      See identical proteins and their annotated locations for NP_001257912.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC078825, CB740494, DV727747
      UniProtKB/TrEMBL
      A0A0G2JVK2, Q6AYZ4
      Related
      ENSRNOP00000047912.2, ENSRNOT00000048851.5
      Conserved Domains (1) summary
      cd07414
      Location:8298
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
    2. NM_022498.2NP_071943.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

      See identical proteins and their annotated locations for NP_071943.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1).
      Source sequence(s)
      CB740494, DV727747, FM102812, FM122849, FN803249
      UniProtKB/Swiss-Prot
      P63088
      UniProtKB/TrEMBL
      A0A8I5ZJ60, A6J1B7
      Related
      ENSRNOP00000071829.1, ENSRNOT00000078761.3
      Conserved Domains (1) summary
      cd07414
      Location:8298
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40043822..40061301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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