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    Sts steroid sulfatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24800, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stsprovided by RGD
    Official Full Name
    steroid sulfataseprovided by RGD
    Primary source
    RGD:3783
    See related
    EnsemblRapid:ENSRNOG00000032487 AllianceGenome:RGD:3783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables steryl-sulfatase activity. Involved in several processes, including response to estrogen; response to pH; and response to peptide hormone. Located in endoplasmic reticulum membrane and nuclear envelope. Biomarker of cryptorchidism and hypertension. Human ortholog(s) of this gene implicated in X-linked ichthyosis. Orthologous to human STS (steroid sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 60.7), Adrenal (RPKM 59.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sts in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (46102524..46110868)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (42225131..42233403)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (45420418..45428748)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene anomalous homeobox Neighboring gene prostaglandin E synthase 3-like 1 Neighboring gene patatin like phospholipase domain containing 4 Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the rat steroid sulfatase gene (Sts), a non-pseudoautosomal X-linked gene that undergoes X inactivation. Li XM, et al. Mamm Genome, 1996 Jun. PMID 8662223
    2. Testicular steroid sulfatase in a cryptorchid rat strain. Mouhadjer N, et al. J Steroid Biochem, 1989. PMID 2576297
    3. A monoclonal antibody to rat liver arylsulfatase C and its application in immunohistochemistry. Kawano J, et al. J Histochem Cytochem, 1989 May. PMID 2703703
    4. Secretory pattern of growth hormone regulates steroid sulfatase activity in rat liver. Eriksson L, et al. J Steroid Biochem, 1989 Sep. PMID 2779233
    5. Effects of estrogen and growth hormone on steroid sulfatase activity and estrogen binding in rat liver. Nilsson B, et al. J Steroid Biochem, 1988 Mar. PMID 2965775

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arylsulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steryl-sulfatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfuric ester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to estrogen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to peptide hormone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in skin development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    steryl-sulfatase
    Names
    ASC
    arylsulfatase C
    steroid sulfatase (microsomal), isozyme S
    steryl-sulfate sulfohydrolase
    NP_036793.2
    XP_006257023.1
    XP_006257024.1
    XP_063135863.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012661.2 → NP_036793.2  steryl-sulfatase precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P15589
      UniProtKB/TrEMBL
      A6IPT8, G3V9E5
      Conserved Domains (1) summary
      cl23718
      Location:26 → 548
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      46102524..46110868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256961.5 → XP_006257023.1  steryl-sulfatase isoform X1

      See identical proteins and their annotated locations for XP_006257023.1

      UniProtKB/Swiss-Prot
      P15589
      UniProtKB/TrEMBL
      A6IPT8, G3V9E5
      Related
      ENSRNOP00000043915.4, ENSRNOT00000051897.6
      Conserved Domains (1) summary
      cl23718
      Location:26 → 548
      ALP_like; alkaline phosphatases and sulfatases

    2. XM_006256962.5 → XP_006257024.1  steryl-sulfatase isoform X2

      UniProtKB/Swiss-Prot
      P15589
      Conserved Domains (2) summary
      COG3119
      Location:26 → 415
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cl23718
      Location:26 → 441
      ALP_like; alkaline phosphatases and sulfatases

    3. XM_063279793.1 → XP_063135863.1  steryl-sulfatase isoform X2

      UniProtKB/Swiss-Prot
      P15589
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15589.2 GenPept UniProtKB/Swiss-Prot:P15589

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