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    Slc22a8 solute carrier family 22 member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83500, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc22a8provided by RGD
    Official Full Name
    solute carrier family 22 member 8provided by RGD
    Primary source
    RGD:632286
    See related
    EnsemblRapid:ENSRNOG00000018086 AllianceGenome:RGD:632286
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OCT3; Oat3; Roct
    Summary
    Enables organic anion transmembrane transporter activity; protein kinase C binding activity; and quaternary ammonium group transmembrane transporter activity. Involved in glutathione transport; quaternary ammonium group transport; and response to organic cyclic compound. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC22A8 (solute carrier family 22 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1144.8) See more
    Orthologs
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    Genomic context

    See Slc22a8 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (214925506..214945516)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205496331..205516378)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224799444..224818482)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene integral membrane transport protein UST5r Neighboring gene solute carrier family 22, member 25 Neighboring gene enhancer of rudimentary homolog Neighboring gene uncharacterized LOC134483966 Neighboring gene solute carrier family 22 member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93369

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antiporter activity  
    enables antiporter activity  
    enables organic anion transmembrane transporter activity PubMed 
    enables organic anion transmembrane transporter activity  
    enables organic anion transmembrane transporter activity  
    enables prostaglandin transmembrane transporter activity  
    enables prostaglandin transmembrane transporter activity  
    enables protein kinase C binding PubMed 
    enables quaternary ammonium group transmembrane transporter activity PubMed 
    enables quaternary ammonium group transmembrane transporter activity  
    enables solute:inorganic anion antiporter activity  
    enables solute:inorganic anion antiporter activity  
    enables xenobiotic transmembrane transporter activity  
    enables xenobiotic transmembrane transporter activity  
    enables xenobiotic transmembrane transporter activity  
    Process Evidence Code Pubs
    involved_in glutathione transport PubMed 
    involved_in inorganic anion transport  
    involved_in monoatomic ion transport  
    involved_in organic anion transport  
    involved_in prostaglandin transport  
    involved_in prostaglandin transport  
    involved_in prostaglandin transport  
    involved_in quaternary ammonium group transport PubMed 
    involved_in quaternary ammonium group transport  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to toxic substance  
    involved_in transmembrane transport  
    involved_in xenobiotic transport  
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  

    General protein information

    Preferred Names
    organic anion transporter 3
    Names
    organic anion/dicarboxylate exchanger
    rOat3
    solute carrier family 22 (organic anion transporter), member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031332.1NP_112622.1  organic anion transporter 3

      See identical proteins and their annotated locations for NP_112622.1

      Status: PROVISIONAL

      Source sequence(s)
      AB017446
      UniProtKB/Swiss-Prot
      Q66HN0, Q9R1U7
      UniProtKB/TrEMBL
      A0A0G2JSQ3, A6HZR4
      Related
      ENSRNOP00000084369.2, ENSRNOT00000100942.2
      Conserved Domains (2) summary
      cd06174
      Location:124492
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11503
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      214925506..214945516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092475.2XP_038948403.1  organic anion transporter 3 isoform X1

      Conserved Domains (1) summary
      TIGR00898
      Location:1380
      2A0119; cation transport protein
    2. XM_008760243.4XP_008758465.1  organic anion transporter 3 isoform X1

      Conserved Domains (1) summary
      TIGR00898
      Location:1380
      2A0119; cation transport protein
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