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    Fbp2 fructose-bisphosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114508, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbp2provided by RGD
    Official Full Name
    fructose-bisphosphatase 2provided by RGD
    Primary source
    RGD:620930
    See related
    EnsemblRapid:ENSRNOG00000017637 AllianceGenome:RGD:620930
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FBPase
    Summary
    Enables fructose 1,6-bisphosphate 1-phosphatase activity. Involved in gluconeogenesis. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Orthologous to human FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 425.9), Testes (RPKM 83.5) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Fbp2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (2241767..2259371)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (2236088..2253702)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (372554..389918, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551048 Neighboring gene fructose-bisphosphatase 1 Neighboring gene uncharacterized LOC134482657 Neighboring gene zinc finger protein 715, pseudogene 1 Neighboring gene ATPase H+ transporting V1 subunit G1, pseudogene 1 Neighboring gene zinc finger protein 715, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in fructose 1,6-bisphosphate metabolic process  
    involved_in fructose 6-phosphate metabolic process  
    involved_in fructose metabolic process  
    involved_in gluconeogenesis  
    involved_in gluconeogenesis PubMed 
    involved_in gluconeogenesis  
    Component Evidence Code Pubs
    located_in Z disc  
    located_in anchoring junction  
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    fructose-1,6-bisphosphatase isozyme 2
    Names
    D-fructose-1,6-bisphosphate 1-phosphohydrolase 2
    FBPase 2
    fructose-1,6-bisphosphatase 2
    muscle FBPase
    NP_446168.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053716.2NP_446168.1  fructose-1,6-bisphosphatase isozyme 2

      See identical proteins and their annotated locations for NP_446168.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q9Z1N1
      UniProtKB/TrEMBL
      A6KQB2
      Related
      ENSRNOP00000023865.2, ENSRNOT00000023865.5
      Conserved Domains (1) summary
      cd00354
      Location:18330
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      2241767..2259371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005495224.2 RNA Sequence

    2. XR_005495226.2 RNA Sequence

    3. XR_010058804.1 RNA Sequence

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