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    Rock1 Rho-associated coiled-coil containing protein kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81762, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rock1provided by RGD
    Official Full Name
    Rho-associated coiled-coil containing protein kinase 1provided by RGD
    Primary source
    RGD:620424
    See related
    EnsemblRapid:ENSRNOG00000031092 AllianceGenome:RGD:620424
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ROCK-I; P160Rock
    Summary
    Enables small GTPase binding activity. Involved in cytoskeleton organization; positive regulation of gene expression; and response to transforming growth factor beta. Acts upstream of or within Rho protein signal transduction. Is active in synapse. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 255.8), Lung (RPKM 241.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rock1 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1387360..1509218, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (1114532..1236345, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1273490..1390790, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482897 Neighboring gene THO complex subunit 1 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene NDUFA4, mitochondrial complex associated, pseudogene 2 Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC3-like Neighboring gene ribosomal protein L36A, pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables metal ion binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    enables small GTPase binding  
    enables small GTPase binding PubMed 
    Items 1 - 25 of 30
    Items 1 - 25 of 107
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction  
    acts_upstream_of_or_within Rho protein signal transduction PubMed 
    involved_in Rho protein signal transduction  
    involved_in actin cytoskeleton organization  
    acts_upstream_of_or_within actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in actomyosin structure organization  
    involved_in aortic valve morphogenesis  
    involved_in apical constriction  
    acts_upstream_of_or_within apical constriction  
    involved_in apoptotic process  
    involved_in bleb assembly  
    acts_upstream_of_or_within bleb assembly  
    involved_in blood vessel diameter maintenance  
    involved_in blood vessel diameter maintenance  
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in chromatin remodeling  
    involved_in cortical actin cytoskeleton organization  
    involved_in cytoskeleton organization PubMed 
    involved_in embryonic morphogenesis  
    involved_in epithelial to mesenchymal transition  
    involved_in epithelial to mesenchymal transition  
    involved_in leukocyte cell-cell adhesion  
    involved_in leukocyte migration  
    involved_in leukocyte tethering or rolling  
    involved_in leukocyte tethering or rolling  
    involved_in mRNA destabilization  
    involved_in mRNA destabilization  
    involved_in membrane to membrane docking  
    involved_in membrane to membrane docking  
    involved_in mitotic cytokinesis  
    involved_in motor neuron apoptotic process  
    acts_upstream_of motor neuron apoptotic process  
    involved_in myoblast migration  
    involved_in myoblast migration  
    involved_in myoblast migration  
    involved_in negative regulation of amyloid precursor protein catabolic process  
    involved_in negative regulation of amyloid-beta formation  
    involved_in negative regulation of amyloid-beta formation  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of bicellular tight junction assembly  
    involved_in negative regulation of bicellular tight junction assembly  
    involved_in negative regulation of biomineral tissue development  
    involved_in negative regulation of motor neuron apoptotic process  
    acts_upstream_of_or_within negative regulation of motor neuron apoptotic process  
    involved_in neuron projection arborization  
    involved_in neuron projection arborization  
    involved_in neuron projection development  
    involved_in peptidyl-serine phosphorylation  
    involved_in podocyte cell migration  
    involved_in podocyte cell migration  
    involved_in podocyte cell migration  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of amyloid-beta clearance  
    involved_in positive regulation of amyloid-beta clearance  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of connective tissue replacement  
    involved_in positive regulation of connective tissue replacement  
    involved_in positive regulation of dephosphorylation  
    involved_in positive regulation of dephosphorylation  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of phosphatase activity  
    involved_in positive regulation of protein localization to nucleus  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    acts_upstream_of_or_within regulation of actin filament-based process  
    involved_in regulation of angiotensin-activated signaling pathway  
    involved_in regulation of angiotensin-activated signaling pathway  
    involved_in regulation of cell junction assembly  
    involved_in regulation of cell migration  
    involved_in regulation of cell migration  
    involved_in regulation of cell migration  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of keratinocyte differentiation  
    involved_in regulation of keratinocyte differentiation  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of neuron differentiation  
    involved_in regulation of neuron differentiation  
    involved_in regulation of synapse maturation  
    involved_in regulation of synapse maturation  
    involved_in regulation of synaptic vesicle endocytosis  
    involved_in regulation of synaptic vesicle endocytosis  
    involved_in response to angiotensin  
    involved_in response to angiotensin  
    involved_in response to transforming growth factor beta  
    involved_in response to transforming growth factor beta PubMed 
    involved_in response to transforming growth factor beta  
    Items 1 - 25 of 107
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in Golgi membrane  
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    located_in bleb  
    located_in centriole  
    is_active_in cytoplasm  
    is_active_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule  
    is_active_in cytoskeleton  
    located_in cytoskeleton  
    located_in cytoskeleton  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in ruffle  
    located_in ruffle  
    located_in ruffle  
    is_active_in synapse PubMed 
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    rho-associated protein kinase 1
    Names
    Rho-associated coiled-coil forming kinase 1
    Rho-associated kinase beta
    liver regeneration-related protein LRRG199
    p150 RhoA-binding kinase ROK beta
    p160 ROCK-1
    rho-associated, coiled-coil-containing protein kinase 1
    rho-associated, coiled-coil-containing protein kinase I
    NP_001376168.1
    XP_006254463.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389239.1NP_001376168.1  rho-associated protein kinase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      D4A5S0
      Related
      ENSRNOP00000047378.7, ENSRNOT00000051362.7
      Conserved Domains (6) summary
      cd11639
      Location:489554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      cd01242
      Location:11191225
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      TIGR02168
      Location:4261097
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22250
      Location:836913
      ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase
      cd20874
      Location:12221290
      C1_ROCK1; protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 1 (ROCK1) and similar proteins

    RNA

    1. NR_171200.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      1387360..1509218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254401.5XP_006254463.1  rho-associated protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      D4A5S0
      Conserved Domains (7) summary
      cd11639
      Location:488553
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      smart00220
      Location:76338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:12281282
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:11181224
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      TIGR02168
      Location:4251096
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam08912
      Location:9481013
      Rho_Binding; Rho Binding

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