Rabep2 rabaptin, RAB GTPase binding effector protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rabep2provided by RGD
Official Full Name: rabaptin, RAB GTPase binding effector protein 2provided by RGD
Primary source: RGD:621416
See related: EnsemblRapid:ENSRNOG00000018462 AllianceGenome:RGD:621416
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fra; MP13
Summary: Predicted to enable GTPase activator activity and growth factor activity. Predicted to be involved in regulation of cilium assembly. Predicted to be located in centrosome; ciliary basal body; and cytosol. Predicted to be active in intracellular membrane-bounded organelle. Biomarker of cocaine dependence and nicotine dependence. Orthologous to human RABEP2 (rabaptin, RAB GTPase binding effector protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 135.3), Testes (RPKM 133.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190433501..190457241)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181010305..181026651)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (197839583..197855953)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fos-related antigen 2 has a role in controlling protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts
Title: Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts.
effect of immunoneutralization of endogenous prolactin on expression of FRAs in the tuberoinfundibular dopaminergic, tuberohypophysial dopaminergic and periventricular hypothalamic dopaminergic subpopulations of the hypothalamic dopaminergic neurons
Title: Decreased expression of fos-related antigens (FRAs) in the hypothalamic dopaminergic neurons after immunoneutralization of endogenous prolactin.
Expression of Fos-related antigens is an indicator of neuronal activation in hypothalamic dopaminergic neurons after prolactin administration.
Title: Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI462746 (e-PCR)
- UniSTS:164365

RH143891 (e-PCR)
- UniSTS:233137

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rab GTPase-binding effector protein 2

Names: Fos-related antigen; rabaptin-5beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030585.2 → NP_085074.2 rab GTPase-binding effector protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q62835

UniProtKB/TrEMBL

F1LQC4, Q5EBC7

Related

ENSRNOP00000025043.6, ENSRNOT00000025043.9

Conserved Domains (2) summary

pfam03528
Location:26 → 168

Rabaptin

pfam09311
Location:276 → 531

Rab5-bind; Rabaptin-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

190433501..190457241

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274956.1 → XP_063131026.1 rab GTPase-binding effector protein 2 isoform X1

UniProtKB/Swiss-Prot

Q62835

UniProtKB/TrEMBL

A6I951
XM_039091811.2 → XP_038947739.1 rab GTPase-binding effector protein 2 isoform X2

UniProtKB/TrEMBL

A6I955

Conserved Domains (1) summary

pfam09311
Location:131 → 386

Rab5-bind; Rabaptin-like protein