Aifm3 AIF family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aifm3provided by RGD
Official Full Name: AIF family member 3provided by RGD
Primary source: RGD:1306028
See related: EnsemblRapid:ENSRNOG00000037957 AllianceGenome:RGD:1306028
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306028
Summary: Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human AIFM3 (AIF family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 77.5), Kidney (RPKM 13.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (97009100..97030601, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (83504859..83523630, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (87364452..87380705)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AIF participates in GM-induced apoptosis of vestibular hair cells.
Title: Apoptosis-inducing factor is involved in gentamicin-induced vestibular hair cell death.
Apoptosis-inducing factor is involved in apoptotic-like death of cerebellar granule neurons and could be an alternative mechanism of neuronal death during cerebellar development.
Title: Role for apoptosis-inducing factor in the physiological death of cerebellar neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apoptosis-inducing factor 3

Names: apoptosis inducing factor, mitochondria associated 3; apoptosis-inducing factor, mitochondrion-associated 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013977.3 → NP_001013999.2 apoptosis-inducing factor 3

Status: VALIDATED

Source sequence(s)

CB769270, JAXUCZ010000011

UniProtKB/TrEMBL

D3ZF03

Related

ENSRNOP00000048427.2, ENSRNOT00000040978.6

Conserved Domains (5) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam00070
Location:333 → 413

Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

pfam07992
Location:194 → 492

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:511 → 561

Reductase_C; Reductase C-terminal

cl21454
Location:195 → 284

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

97009100..97030601 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270455.1 → XP_063126525.1 apoptosis-inducing factor 3 isoform X2

UniProtKB/TrEMBL

A0A8I6A793

Related

ENSRNOP00000088997.1, ENSRNOT00000112032.2
XM_039088260.2 → XP_038944188.1 apoptosis-inducing factor 3 isoform X1

Conserved Domains (3) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:194 → 492

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:511 → 561

Reductase_C; Reductase C-terminal
XM_063270454.1 → XP_063126524.1 apoptosis-inducing factor 3 isoform X2

UniProtKB/TrEMBL

A0A8I6A793
XM_039088259.2 → XP_038944187.1 apoptosis-inducing factor 3 isoform X1

Conserved Domains (3) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:194 → 492

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:511 → 561

Reductase_C; Reductase C-terminal
XM_008768875.4 → XP_008767097.1 apoptosis-inducing factor 3 isoform X1

Conserved Domains (3) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:194 → 492

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:511 → 561

Reductase_C; Reductase C-terminal
XM_063270456.1 → XP_063126526.1 apoptosis-inducing factor 3 isoform X3