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    Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363239, updated on 9-Dec-2024

    Summary

    Official Symbol
    Raph1provided by RGD
    Official Full Name
    Ras association (RalGDS/AF-6) and pleckstrin homology domains 1provided by RGD
    Primary source
    RGD:1308387
    See related
    EnsemblRapid:ENSRNOG00000014722 AllianceGenome:RGD:1308387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in signal transduction. Predicted to act upstream of or within axon extension. Predicted to be located in cell leading edge and nuclear body. Predicted to be active in cytosol and plasma membrane. Orthologous to human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 138.8), Liver (RPKM 131.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Raph1 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (69397272..69484174, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61907476..61990170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67290004..67370208, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit c locus 2, pseudogene 1 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene abl-interactor 2 Neighboring gene uncharacterized LOC102547711 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension  
    involved_in biological_process  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in cell leading edge  
    is_active_in cytosol  
    located_in cytosol  
    located_in nuclear body  
    located_in nuclear body  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    ras-associated and pleckstrin homology domains-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108798.2NP_001102268.2  ras-associated and pleckstrin homology domains-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZU51
      Related
      ENSRNOP00000081933.2, ENSRNOT00000102881.2
      Conserved Domains (3) summary
      cd01259
      Location:393515
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:398506
      PH; PH domain
      cl00155
      Location:270351
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      69397272..69484174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267382.1XP_063123452.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      A6IPD1
    2. XM_063267381.1XP_063123451.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      D4ADX8
    3. XM_039083870.2XP_038939798.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      D4ADX8
      Conserved Domains (2) summary
      cd01259
      Location:445567
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:320409
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)
    4. XM_039083868.2XP_038939796.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AMM7, A6IPC9
      Related
      ENSRNOP00000033491.7, ENSRNOT00000036194.8
      Conserved Domains (2) summary
      cd01259
      Location:445567
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:320409
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)
    5. XM_039083863.2XP_038939791.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL54
      Related
      ENSRNOP00000078550.1, ENSRNOT00000106942.2
      Conserved Domains (2) summary
      cd01259
      Location:418540
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:293382
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)
    6. XM_039083862.2XP_038939790.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AF23
      Related
      ENSRNOP00000093050.1, ENSRNOT00000110139.2
      Conserved Domains (2) summary
      cd01259
      Location:420542
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:295384
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)
    7. XM_039083861.2XP_038939789.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A272
      Related
      ENSRNOP00000084951.1, ENSRNOT00000119642.2
      Conserved Domains (2) summary
      cd01259
      Location:445567
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:320409
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)
    8. XM_063267379.1XP_063123449.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AMM7
    9. XM_063267380.1XP_063123450.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AMM7
    10. XM_039083864.2XP_038939792.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X4

      Conserved Domains (2) summary
      cd01259
      Location:384506
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:259348
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)
    11. XM_039083866.1XP_038939794.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X5

    12. XM_039083869.2XP_038939797.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      D4ADX8
      Conserved Domains (2) summary
      cd01259
      Location:445567
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:320409
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

    RNA

    1. XR_005488933.2 RNA Sequence

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