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    Dhrs7b dehydrogenase/reductase 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287380, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dhrs7bprovided by RGD
    Official Full Name
    dehydrogenase/reductase 7Bprovided by RGD
    Primary source
    RGD:1311243
    See related
    EnsemblRapid:ENSRNOG00000005360 AllianceGenome:RGD:1311243
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311243
    Summary
    Predicted to enable DNA-binding transcription factor binding activity and transcription corepressor activity. Predicted to be involved in ether lipid biosynthetic process and neutrophil differentiation. Predicted to act upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Predicted to be located in nucleus and peroxisome. Predicted to be part of transcription regulator complex. Predicted to be active in membrane. Orthologous to human DHRS7B (dehydrogenase/reductase 7B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 95.0), Thymus (RPKM 81.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dhrs7b in Genome Data Viewer
    Location:
    10q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46003845..46036498)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45504344..45537094)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47065755..47111089)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene serine hydroxymethyltransferase 1 Neighboring gene basic transcription factor 3, pseudogene 15 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene transmembrane protein 11 Neighboring gene uncharacterized LOC102546946 Neighboring gene N-acetyltransferase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC105547

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in adipose tissue development  
    acts_upstream_of_or_within adipose tissue development  
    involved_in brown fat cell differentiation  
    acts_upstream_of_or_within brown fat cell differentiation  
    involved_in ether lipid biosynthetic process  
    involved_in ether lipid biosynthetic process  
    involved_in inflammatory response  
    acts_upstream_of inflammatory response  
    involved_in negative regulation of DNA-templated transcription  
    involved_in neutrophil differentiation  
    involved_in neutrophil differentiation  
    involved_in phosphatidylcholine biosynthetic process  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    involved_in regulation of cold-induced thermogenesis  
    acts_upstream_of_or_within regulation of cold-induced thermogenesis  
    acts_upstream_of_or_within regulation of gene expression  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane  
    is_active_in membrane  
    located_in membrane  
    located_in membrane  
    located_in nucleus  
    located_in nucleus  
    located_in peroxisome  
    located_in peroxisome  
    part_of transcription regulator complex  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    dehydrogenase/reductase SDR family member 7B
    Names
    SDR family dehydrogenase/reductase member 7B
    dehydrogenase/reductase (SDR family) member 7B
    short-chain dehydrogenase/reductase family 32C member 1
    NP_001008507.1
    XP_006246534.1
    XP_006246535.1
    XP_038941333.1
    XP_038941334.1
    XP_038941335.1
    XP_038941337.1
    XP_063124693.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008507.1NP_001008507.1  dehydrogenase/reductase SDR family member 7B

      See identical proteins and their annotated locations for NP_001008507.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086453
      UniProtKB/Swiss-Prot
      A4GWE3, Q5RJY4
      UniProtKB/TrEMBL
      A0A8L2R5J7, A6HF59
      Related
      ENSRNOP00000063744.4, ENSRNOT00000065294.4
      Conserved Domains (2) summary
      cd05332
      Location:50311
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      PRK06181
      Location:52321
      PRK06181; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46003845..46036498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085407.2XP_038941335.1  dehydrogenase/reductase SDR family member 7B isoform X2

      UniProtKB/TrEMBL
      A6HF60
      Conserved Domains (1) summary
      cd05332
      Location:50257
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    2. XM_039085409.2XP_038941337.1  dehydrogenase/reductase SDR family member 7B isoform X3

      UniProtKB/TrEMBL
      A0A8L2R5J7
      Conserved Domains (1) summary
      cl21454
      Location:50280
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_039085405.2XP_038941333.1  dehydrogenase/reductase SDR family member 7B isoform X1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61
      Conserved Domains (1) summary
      cd05332
      Location:41302
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    4. XM_039085406.2XP_038941334.1  dehydrogenase/reductase SDR family member 7B isoform X1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61
      Conserved Domains (1) summary
      cd05332
      Location:41302
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    5. XM_006246472.5XP_006246534.1  dehydrogenase/reductase SDR family member 7B isoform X1

      See identical proteins and their annotated locations for XP_006246534.1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61
      Conserved Domains (1) summary
      cd05332
      Location:41302
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    6. XM_063268623.1XP_063124693.1  dehydrogenase/reductase SDR family member 7B isoform X1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61
    7. XM_006246473.5XP_006246535.1  dehydrogenase/reductase SDR family member 7B isoform X1

      See identical proteins and their annotated locations for XP_006246535.1

      UniProtKB/TrEMBL
      A0A8L2QVC0, A6HF61
      Related
      ENSRNOP00000063346.4, ENSRNOT00000066250.5
      Conserved Domains (1) summary
      cd05332
      Location:41302
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
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