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    Fmo2 flavin containing dimethylaniline monoxygenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fmo2provided by RGD
    Official Full Name
    flavin containing dimethylaniline monoxygenase 2provided by RGD
    Primary source
    RGD:628600
    See related
    EnsemblRapid:ENSRNOG00000003510 AllianceGenome:RGD:628600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N,N-dimethylaniline monooxygenase activity. Predicted to be involved in several processes, including NADPH oxidation; toxin metabolic process; and xenobiotic metabolic process. Predicted to act upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and oxygen metabolic process. Predicted to be located in membrane. Orthologous to human FMO2 (flavin containing dimethylaniline monoxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 422.4), Kidney (RPKM 173.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77755131..77777597, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (75221149..75244377, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80752526..80775264, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555487 Neighboring gene flavin containing dimethylaniline monoxygenase 4 Neighboring gene flavin containing dimethylaniline monoxygenase 1 Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 13 Neighboring gene uncharacterized LOC134481523

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the FMO2 gene in Rattus norvegicus: a good model to study metabolic and toxicological consequences of the FMO2 polymorphism. Hugonnard M, et al. Pharmacogenetics, 2004 Oct. PMID 15454729
    2. Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse. Karoly ED, et al. J Biochem Mol Toxicol, 2001. PMID 11835629
    3. Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. Krueger SK, et al. Drug Metab Dispos, 2002 Jan. PMID 11744609
    4. The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein. Dolphin CT, et al. J Biol Chem, 1998 Nov 13. PMID 9804831
    5. The FMO2 gene of laboratory rats, as in most humans, encodes a truncated protein. Lattard V, et al. Biochem Biophys Res Commun, 2002 Mar 29. PMID 11906197

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FMO2 genetic polymorphism was associated with major differences in the S-oxidative metabolism.
      Title: Identification and characterization of the FMO2 gene in Rattus norvegicus: a good model to study metabolic and toxicological consequences of the FMO2 polymorphism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADPH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADPH oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxygen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oxygen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toxin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dimethylaniline monooxygenase [N-oxide-forming] 2
    Names
    FMO 2
    dimethylaniline oxidase 2
    flavin containing monooxygenase 2
    pulmonary flavin-containing monooxygenase 2
    NP_653338.2
    XP_063128091.1
    XP_063128092.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144737.2 → NP_653338.2  dimethylaniline monooxygenase [N-oxide-forming] 2

      See identical proteins and their annotated locations for NP_653338.2

      Status: VALIDATED

      Source sequence(s)
      BC070904, CK365136
      UniProtKB/Swiss-Prot
      Q6IRI9
      UniProtKB/TrEMBL
      A6IDA6, G3V6F6
      Related
      ENSRNOP00000004762.3, ENSRNOT00000004762.7
      Conserved Domains (3) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like
      pfam13450
      Location:7 → 58
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:78 → 340
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      77755131..77777597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272021.1 → XP_063128091.1  dimethylaniline monooxygenase [N-oxide-forming] 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6IRI9
      UniProtKB/TrEMBL
      A6IDA6, G3V6F6

    2. XM_063272022.1 → XP_063128092.1  dimethylaniline monooxygenase [N-oxide-forming] 2 isoform X2

    RNA

    1. XR_005492201.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IRI9.3 GenPept UniProtKB/Swiss-Prot:Q6IRI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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